Mitochondrial gateways to cancer

L Galluzzi, E Morselli, O Kepp, I Vitale, A Rigoni… - Molecular aspects of …, 2010 - Elsevier
Mitochondria are required for cellular survival, yet can also orchestrate cell death. The
peculiar biochemical properties of these organelles, which are intimately linked to their …

Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry

T Notter, JM Coughlin, A Sawa, U Meyer - Molecular psychiatry, 2018 - nature.com
A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …

The role of translocator protein TSPO in hallmarks of glioblastoma

LM Ammer, A Vollmann-Zwerenz, V Ruf, CH Wetzel… - Cancers, 2020 - mdpi.com
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …

Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products

JI Webster, EM Sternberg - Journal of Endocrinology, 2004 - joe.bioscientifica.com
The present study was undertaken to investigate heat stress protein (HSP)-70 mRNA
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria

J Gatliff, M Campanella - Biochemical Journal, 2016 - portlandpress.com
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane
(OMM) of cells and is readily up-regulated under various pathological conditions such as …

The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression

L Veenman, M Gavish - Current molecular medicine, 2012 - ingentaconnect.com
The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to
bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its …

Mitochondrial remodeling in cancer metabolism and survival: potential for new therapies

IA Barbosa, NG Machado, AJ Skildum, PM Scott… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Mitochondria are semi-autonomous organelles that play essential roles in cellular
metabolism and programmed cell death pathways. Genomic, functional and structural …

TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

AN Menevse, LM Ammer, A Vollmann-Zwerenz… - Acta Neuropathologica …, 2023 - Springer
Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly
resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in …

Obesity-induced down-regulation of the mitochondrial translocator protein (TSPO) impairs placental steroid production

L Lassance, M Haghiac, J Minium… - The Journal of …, 2015 - academic.oup.com
Context: Low concentrations of estradiol and progesterone are hallmarks of adverse
pregnancy outcomes as is maternal obesity. During pregnancy, placental cholesterol is the …

CoCl2 Induces Apoptosis via the 18 kDa Translocator Protein in U118MG Human Glioblastoma Cells

S Zeno, M Zaaroor, S Leschiner, L Veenman… - Biochemistry, 2009 - ACS Publications
The 18 kDa translocator protein (TSPO), formerly known as the peripheral-type
benzodiazepine receptor, has been reported to be closely associated with the mitochondrial …