m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

Potential non-invasive biomarkers in tumor immune checkpoint inhibitor therapy: response and prognosis prediction

R Song, F Liu, Y Ping, Y Zhang, L Wang - Biomarker Research, 2023 - Springer
Immune checkpoint inhibitors (ICIs) have dramatically enhanced the treatment outcomes for
diverse malignancies. Yet, only 15–60% of patients respond significantly. Therefore …

Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming

X Han, Y Zhu, J Ke, Y Zhai, M Huang, X Zhang… - Cell Death …, 2024 - nature.com
Abstract Recently, N6-methyladenosine (m6A) has aroused widespread discussion in the
scientific community as a mode of RNA modification. m6A comprises writers, erasers, and …

17β-hydroxysteroid dehydrogenases in the progression of nonalcoholic fatty liver disease

MX Wang, ZG Peng - Pharmacology & Therapeutics, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic and a major
public health problem, with a prevalence of approximately 25%. The pathogenesis of …

RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

WW Liu, SQ Zheng, T Li, YF Fei, C Wang… - … and Targeted Therapy, 2024 - nature.com
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis
requirements of cells. Relevant studies have been constantly making inroads in our …

N6-methyladenosine demethyltransferase FTO mediated m6A modification of estrogen receptor alpha in non-small cell lung cancer tumorigenesis

X Xu, S Qiu, B Zeng, Y Huang, X Wang, F Li, Y Yang… - Oncogene, 2024 - nature.com
Fat mass and obesity-associated protein (FTO), which is closely linked with obesity and
dietary intake, plays an important role in diet-related metabolic diseases. However, the …

[HTML][HTML] Lipid metabolism analysis in esophageal cancer and associated drug discovery

R Jiao, W Jiang, K Xu, Q Luo, L Wang… - Journal of Pharmaceutical …, 2024 - Elsevier
Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis. It is still
being explored in depth due to its complex molecular mechanisms of occurrence and …

FTO: a critical role in obesity and obesity-related diseases

D Yin, Y Li, X Liao, D Tian, Y Xu, C Zhou… - British Journal of …, 2023 - cambridge.org
In recent years, obesity is a growing pandemic in the world and has likely contributed to
increasing the incidence of obesity-related diseases. Fat mass and obesity-associated gene …

PIKE-A modulates mitochondrial metabolism through increasing SDHA expression mediated by STAT3/FTO Axis

M Sun, Q Yan, Y Qiao, H Zhao, Y Wang… - International Journal of …, 2022 - mdpi.com
Previous studies have shown that phosphoinositide 3-kinase enhancer-activating Akt (PIKE-
A) is involved in the regulation of several biological processes in cancer. In our previous …

[HTML][HTML] The roles of m6A RNA methylation modification in cancer stem cells: new opportunities for cancer suppression

H Chen, H Li, W Shi, H Qin, L Zheng - Cancer Insight, 2022 - anserpress.org
As a reversible post-transcriptional modification, N6-methyladeno sine is the most common
form of RNA modification in eukaryotic mRNA. Cancer stem cells (CSCs), which are a …