Abstract The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and
has been considered a promising therapeutic target. Many of the positive regulators of the …

Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …

For the past twenty years, chemokines have emerged as a family of critical mediators of cell
migration during immune surveillance, development, inflammation and cancer progression …

Endocrine-based treatments are the normal standard-of-care in women with hormone
receptor-positive/Human Epidermal growth factor Receptor 2-negative metastatic breast …

Summary The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network
plays fundamental roles in cell growth, survival, and migration and is frequently activated in …

Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …

Abstract INPP4B suppresses PI3K/AKT signaling by converting PI (3, 4) P2 to PI (3) P and
INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is …

Class I phosphoinositide 3-kinase (PI3K) generates phosphatidylinositol 3, 4, 5-
trisphosphate (PtdIns (3, 4, 5) P 3) at the plasma membrane in response to growth factors …

Innate lymphoid cells (ILCs) are a heterogeneous population of lymphocytes that coordinate
early immune responses and maintain tissue homeostasis. Type 1 innate immune …

Inactivation of the tumor suppressor lipid phosphatase INPP4B is common in triple-negative
breast cancer (TNBC). We generated a genetically engineered TNBC mouse model …