The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology

C Esser, A Rannug - Pharmacological reviews, 2015 - ASPET
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to
the Per-ARNT-Sim–basic helix-loop-helix protein family. AhR translocates into the nucleus …

Chemistry and properties of indolocarbazoles

T Janosik, A Rannug, U Rannug, N Wahlström… - Chemical …, 2018 - ACS Publications
The indolocarbazoles are an important class of nitrogen heterocycles which has evolved
significantly in recent years, with numerous studies focusing on their diverse biological …

An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

JD Mezrich, JH Fechner, X Zhang… - The Journal of …, 2010 - journals.aai.org
The aryl hydrocarbon receptor (AHR) has been known to cause immunosuppression after
binding dioxin. It has recently been discovered that the receptor may be central to T cell …

Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

E Wincent, J Bengtsson, AM Bardbori… - Proceedings of the …, 2012 - National Acad Sciences
Altered systemic levels of 6-formylindolo [3, 2-b] carbazole (FICZ), an enigmatic endogenous
ligand for the aryl hydrocarbon receptor (AHR), may explain adverse physiological …

[HTML][HTML] A new insight into the potential role of tryptophan-derived AhR ligands in skin physiological and pathological processes

M Szelest, K Walczak, T Plech - International journal of molecular …, 2021 - mdpi.com
The aryl hydrocarbon receptor (AhR) plays a crucial role in environmental responses and
xenobiotic metabolism, as it controls the transcription profiles of several genes in a ligand …

The tryptophan derivative 6-formylindolo[3,2-b]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and …

A Rannug, U Rannug - Critical reviews in toxicology, 2018 - Taylor & Francis
The aryl hydrocarbon receptor (AHR) is not essential to survival, but does act as a key
regulator of many normal physiological events. The role of this receptor in toxicological …

[HTML][HTML] Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production

MM Lowe, JE Mold, B Kanwar, Y Huang, A Louie… - PloS one, 2014 - journals.plos.org
The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic
halogenated aromatic hydrocarbons and is involved in a diverse array of biological …

[HTML][HTML] The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells

EA Stanford, Z Wang, O Novikov, F Mulas… - BMC biology, 2016 - Springer
Background Self-renewing, chemoresistant breast cancer stem cells are believed to
contribute significantly to cancer invasion, migration and patient relapse. Therefore, the …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio)

N Blüthgen, N Meili, G Chew, A Odermatt… - Science of the Total …, 2014 - Elsevier
Wide application of the UV-filter octocrylene (OC) in cosmetics leads to contamination of the
aquatic environment, but effects of OC remain unclear. Here we determine bioaccumulation …