Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Polyoxometalates as potential next‐generation metallodrugs in the combat against cancer

A Bijelic, M Aureliano, A Rompel - … Chemie International Edition, 2019 - Wiley Online Library
Polyoxometalates (POMs) are an emerging class of inorganic metal oxides, which over the
last decades demonstrated promising biological activities by the virtue of their great diversity …

Polyoxometalate-based radiosensitization platform for treating hypoxic tumors by attenuating radioresistance and enhancing radiation response

Y Yong, C Zhang, Z Gu, J Du, Z Guo, X Dong, J Xie… - ACS …, 2017 - ACS Publications
Radioresistance is one of the undesirable impediments in hypoxic tumors, which sharply
diminishes the therapeutic effectiveness of radiotherapy and eventually results in the failure …

Polyoxometalates impact as anticancer agents

F Carvalho, M Aureliano - International journal of molecular sciences, 2023 - mdpi.com
Polyoxometalates (POMs) are oxoanions of transition metal ions, such as V, Mo, W, Nb, and
Pd, forming a variety of structures with a wide range of applications. Herein, we analyzed …

Polyoxometalates in biomedicine: Update and overview

MB Čolović, M Lacković, J Lalatović… - Current medicinal …, 2020 - ingentaconnect.com
Background: Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early
transition metal ions in high oxidation states (eg, WVI, MoVI, VV). POMs are of interest in the …

The future of polyoxymetalates for biological and chemical apllications

MJW Budych, K Staszak, A Bajek, F Pniewski… - Coordination Chemistry …, 2023 - Elsevier
This paper reports the most interesting applications of polyoxometalates (POMs) over the
last five years, highlighting the relationship between their complex nature, properties, and …

A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

M Arefian, M Mirzaei, H Eshtiagh-Hosseini… - Dalton …, 2017 - pubs.rsc.org
One of the most attractive areas in inorganic chemistry is the synthesis of polyoxometalates
(POMs) exhibiting new properties and applications. Since the impact of POMs in …

The future is bright for polyoxometalates

M Aureliano - BioChem, 2022 - mdpi.com
Polyoxometalates (POMs) are clusters of units of oxoanions of transition metals, such as Mo,
W, V and Nb, that can be formed upon acidification of neutral solutions. Once formed, some …

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer's disease

X Wang, S Wei, C Zhao, X Li, J Jin, X Shi, Z Su… - JBIC Journal of …, 2022 - Springer
As shown in studies conducted in recent decades, polyoxometalates (POMs), as inorganic
metal oxides, have promising biological activities, including antitumor, anti-infectious and …

Polyoxometalate nanoclusters: a potential preventative and therapeutic drug for inflammatory bowel disease

J Wang, Z Tao, T Tian, J Qiu, H Qian, Z Zha… - Chemical Engineering …, 2021 - Elsevier
Although the etiology and pathogenesis of refractory inflammatory bowel diseases (IBD) are
still largely suspended, elimination of reactive oxygen species (ROS) in inflamed colon has …