Cellular and molecular processes in wound healing

M Fernández-Guarino, ML Hernández-Bule, S Bacci - Biomedicines, 2023 - mdpi.com
This review summarizes the recent knowledge of the cellular and molecular processes that
occur during wound healing. However, these biological mechanisms have yet to be defined …

Epigenetic modification mechanisms involved in keloid: current status and prospect

W Lv, Y Ren, K Hou, W Hu, Y Yi, M Xiong, M Wu… - Clinical …, 2020 - Springer
Keloid, a common dermal fibroproliferative disorder, is benign skin tumors characterized by
the aggressive fibroblasts proliferation and excessive accumulation of extracellular matrix …

Keloid: genetic susceptibility and contributions of genetics and epigenetics to its pathogenesis

S Liu, H Yang, J Song, Y Zhang… - Experimental …, 2022 - Wiley Online Library
Keloid, characterized by fibroproliferative disorders of the skin, can be developed in people
of different genders, ages and ethnicities. Keloid can appear in any part of the body but are …

Characterization of the skin keloid microenvironment

M Zhang, H Chen, H Qian, C Wang - Cell Communication and Signaling, 2023 - Springer
Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids
exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the …

Mechanisms underlying pathological scarring by fibroblasts during wound healing

Y Ma, Z Liu, LL Miao, X Jiang, H Ruan… - International Wound …, 2023 - Wiley Online Library
Pathological scarring is an abnormal outcome of wound healing, which often manifests as
excessive proliferation and transdifferentiation of fibroblasts (FBs), and excessive deposition …

The epigenetics of keloids

AW Stevenson, Z Deng, A Allahham… - Experimental …, 2021 - Wiley Online Library
Keloid scarring is a fibroproliferative disorder of the skin with unknown pathophysiology,
characterised by fibrotic tissue that extends beyond the boundaries of the original wound …

Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease

T Rönn, A Perfilyev, J Jönsson… - Human Molecular …, 2023 - academic.oup.com
Dysregulation of circulating lipids is a central element for the metabolic syndrome. However,
it is not well established whether human subcutaneous adipose tissue is affected by or affect …

Genetics and epigenetics of keloids

DT Nyika, NP Khumalo, A Bayat - Advances in Wound Care, 2022 - liebertpub.com
Significance: Keloid scarring is cosmetically disfiguring, psychosocially distressing, and can
be physically disabling. The pathophysiology of keloid formation is poorly understood and …

Tenascin-C: a key regulator in angiogenesis during wound healing

Y Wang, G Wang, H Liu - Biomolecules, 2022 - mdpi.com
(1) Background: Injury repair is a complex physiological process in which multiple cells and
molecules are involved. Tenascin-C (TNC), an extracellular matrix (ECM) glycoprotein, is …

Cellular mechanisms and therapies in wound healing: Looking toward the future

S Bacci - Biomedicines, 2021 - mdpi.com
Wound healing is the process that makes organisms resilient to injuries, enabling survival. It
is of fundamental importance for life, and its basic pathways have been conserved …