Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely
on molecular tools, such as photocleavable protecting groups and photoswitches that …

Covalent kinase inhibitors account for some of the most successful drugs that have recently
entered the clinic and many others are in preclinical development. A common strategy is to …

CRY1 and CRY2 proteins are highly conserved components of the circadian clock that
controls daily physiological rhythms. Disruption of CRY functions are related to many …

Predicting the conversion and selectivity of a photochemical experiment is a conceptually
different challenge compared to thermally induced reactivity. Photochemical transformations …

Daily physiological rhythms are regulated by the body's internal timekeeper known as the
circadian clock. Expression, post-translational modification, and degradation of clock …

Photoexcited dihydronicotinamides like NADH and analogues have been found to generate
alkyl radicals upon reductive decarboxylation of redox-active esters without auxiliary …

Light passes through biological tissue, and so it is used for imaging biological processes in
situ. Such observation is part of the very essence of science, but mechanistic understanding …

Retinoic acid receptor‐related orphan receptor γ (RORγ) is a nuclear hormone receptor with
multiple biological functions in circadian clock regulation, inflammation, and immunity. Its …

Endogenous circadian rhythms are biological processes generated by an internal body
clock. They are self-sustaining, and they govern biochemical and physiological processes …