The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Pyridine (py) is an important heterocyclic compound and is an integral part of various natural
products. There are various medicines containing py ring system being available in the …

Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …

Pyridine and pyrimidine derivatives have received great interest in recent pharmacological
research, being effective in the treatment of various malignancies, such as myeloid …

Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of
Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention …

Herein, we present a novel method for the synthesis of highly functionalized 2, 4-
diarylpyridines. This method involves a one-pot cascade reaction utilizing α, β-unsaturated …

Pyridine and pyridine-fused ring systems are ubiquitous in medicinal research and
demonstrate such diverse pharmacological benefits as anticonvulsant therapies, treatment …

A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14
containing benzo [4, 5] furo [3, 2-b] pyridine core and 15 comprising chromeno [4, 3-b] …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …