Novel and improved biocatalysts are increasingly sourced from libraries via experimental
screening. The success of such campaigns is crucially dependent on the number of …

Modified nucleic acids, also called xeno nucleic acids (XNAs), offer a variety of advantages
for biotechnological applications and address some of the limitations of first-generation …

The COVID-19 pandemic caused by SARS-CoV-2 affects all aspects of human life.
Detection platforms that are efficient, rapid, accurate, specific, sensitive, and user friendly are …

Isothermal nucleic acid amplification tests (iNATs), such as loop-mediated isothermal
amplification (LAMP), are good alternatives to PCR-based amplification assays, especially …

Abstract RT-LAMP detection of SARS-CoV-2 has been shown to be a valuable approach to
scale up COVID-19 diagnostics and thus contribute to limiting the spread of the disease …

As the second year of the COVID-19 pandemic begins, it remains clear that a massive
increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to …

DNA polymerases are a superfamily of enzymes synthesizing DNA using DNA as a
template. They are essential for nucleic acid metabolism and for DNA replication and repair …

The charge states of proteins can greatly influence their stabilities and interactions with
substrates, and the addition of multiple charges (supercharging) has been shown to be a …

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). To counter COVID-19 spreading, an …

The review focuses on the main factors involved in the formation of nonspecific products in
isothermal nucleic acid amplification, such as mispriming, ab initio DNA synthesis, and …