Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise

TEG Krueger, DLJ Thorek… - Stem cells …, 2018 - academic.oup.com
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

[HTML][HTML] Glioblastoma multiforme: State of the art and future therapeutics

TA Wilson, MA Karajannis, DH Harter - Surgical neurology …, 2014 - ncbi.nlm.nih.gov
Background: Glioblastoma multiforme (GBM) is the most common and lethal primary
malignancy of the central nervous system (CNS). Despite the proven benefit of surgical …

Mesenchymal stem cell-mediated effects of tumor support or suppression

KJ Rhee, JI Lee, YW Eom - International journal of molecular sciences, 2015 - mdpi.com
Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many
studies have reported that tumor progression and metastasis increase by MSCs. In contrast …

Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas

C Pendleton, Q Li, DA Chesler, K Yuan… - PloS one, 2013 - journals.plos.org
Introduction Glioblastoma is the most common primary malignant brain tumor, and is
refractory to surgical resection, radiation, and chemotherapy. Human mesenchymal stem …

Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

W Liang, X Chen, S Zhang, J Fang, M Chen… - Cellular & Molecular …, 2021 - Springer
Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous
reports indicate that they are involved in multiple tumor-promoting processes through …

Mesenchymal stem cell–mediated delivery of an oncolytic adenovirus enhances antitumor efficacy in hepatocellular carcinoma

AR Yoon, JW Hong, Y Li, HC Shin, H Lee, HS Kim… - Cancer research, 2019 - AACR
Oncolytic virotherapy is a promising alternative to conventional treatment, yet systemic
delivery of these viruses to tumors remains a major challenge. In this regard, mesenchymal …

Mesenchymal stem cells: from experiment to clinic

WR Otto, NA Wright - Fibrogenesis & Tissue Repair, 2011 - Springer
There is currently much interest in adult mesenchymal stem cells (MSCs) and their ability to
differentiate into other cell types, and to partake in the anatomy and physiology of remote …

Optimizing patient derived mesenchymal stem cells as virus carriers for a phase I clinical trial in ovarian cancer

EK Mader, G Butler, SC Dowdy, A Mariani… - Journal of translational …, 2013 - Springer
Background Mesenchymal stem cells (MSC) can serve as carriers to deliver oncolytic
measles virus (MV) to ovarian tumors. In preparation for a clinical trial to use MSC as MV …

Advances in mesenchymal stem cell-mediated gene therapy for cancer

RM Dwyer, S Khan, FP Barry, T O'Brien… - Stem cell research & …, 2010 - Springer
Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are
also considered immunoprivileged. This remarkable combination of properties has formed …

Mesenchymal stem cells at the intersection of cell and gene therapy

TJ Myers, F Granero-Molto, L Longobardi… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Mesenchymal stem cells have the ability to differentiate into
osteoblasts, chondrocytes and adipocytes. Along with differentiation, MSCs can modulate …