The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Background Adolescent depression may increase risk for poor mental health outcomes in
adulthood. The objective of this study was to systematically review the literature on the …

Aberrant topological organization of whole-brain networks has been inconsistently reported
in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes …

Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of developing mental disorders in later life. However, no review has …

Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The
insular cortex has been suggested to process emotions and homeostatic signals, but how …

The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …

Objective To estimate the comparative clinical efficacy and acceptability of non-surgical
brain stimulation for the acute treatment of major depressive episodes in adults. Design …

Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is
limited in that the optimal therapeutic target remains unknown. Early TMS trials lacked a …

Over the past three decades, insights into the role of the cerebellum in emotional processing
have substantially increased. Indeed, methodological refinements in cerebellar lesion …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …