Synergistic enhancement of cancer therapy using HDAC inhibitors: opportunity for clinical trials
L Hontecillas-Prieto, R Flores-Campos, A Silver… - Frontiers in …, 2020 - frontiersin.org
Chemotherapy is one of the most established and effective treatments for almost all types of
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …
Regulation of chemokines and cytokines by histone deacetylases and an update on histone decetylase inhibitors in human diseases
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …
Light‐controlled histone deacetylase (HDAC) inhibitors: towards photopharmacological chemotherapy
W Szymanski, ME Ourailidou… - … A European Journal, 2015 - Wiley Online Library
Cancer treatment suffers from limitations that have a major impact on the patient's quality of
life and survival. In the case of chemotherapy, the systemic distribution of cytotoxic drugs …
life and survival. In the case of chemotherapy, the systemic distribution of cytotoxic drugs …
Dissecting histone deacetylase 3 in multiple disease conditions: selective inhibition as a promising therapeutic strategy
The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …
states. Modulation of such epigenetic modifications has therefore made histone …
[HTML][HTML] HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by …
NGJ Leus, PE van der Wouden… - Biochemical …, 2016 - Elsevier
The increasing number of patients suffering from chronic obstructive pulmonary disease
(COPD) represents a major and increasing health problem. Therefore, novel therapeutic …
(COPD) represents a major and increasing health problem. Therefore, novel therapeutic …
Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation
NGJ Leus, MRH Zwinderman, FJ Dekker - Current opinion in chemical …, 2016 - Elsevier
Highlights•HDAC 3 plays a key role in NF-κB-mediated signaling.•HDAC inhibitors
demonstrate promising anti-inflammatory effects.•Selective HDAC 3 inhibitors have potential …
demonstrate promising anti-inflammatory effects.•Selective HDAC 3 inhibitors have potential …
Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma
R Islam, D Dash, R Singh - Cytokine, 2022 - Elsevier
Asthma being an inflammatory disease of the airways lead to structural alterations in lungs
which often results in the severity of the disease. Curcumin, diferuloylmethane, is well known …
which often results in the severity of the disease. Curcumin, diferuloylmethane, is well known …
The role of HDAC3 in inflammation: mechanisms and therapeutic implications
N Watson, S Kuppuswamy, WL Ledford… - Frontiers in …, 2024 - frontiersin.org
Histone deacetylases (HDACs) are critical regulators of inflammatory gene expression, and
the efficacy of pan-HDAC inhibitors has been implicated in various disease conditions …
the efficacy of pan-HDAC inhibitors has been implicated in various disease conditions …
The potential use of l-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence
N Mazarakis, K Snibson, PV Licciardi, TC Karagiannis - Clinical nutrition, 2020 - Elsevier
Summary According to the World Health Organisation, 70% of all deaths globally can be
attributed to chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel …
attributed to chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel …
Formation, immunomodulatory activities, and enhancement of glucosinolates and sulforaphane in broccoli sprouts: a review for maximizing the health benefits to …
L Li, P Ma, S Nirasawa, H Liu - Critical Reviews in Food Science …, 2024 - Taylor & Francis
Broccoli sprouts have been considered as functional foods which have received increasing
attention because they have been highly prized for glucosinolates, phenolics, and vitamins …
attention because they have been highly prized for glucosinolates, phenolics, and vitamins …