Synergistic enhancement of cancer therapy using HDAC inhibitors: opportunity for clinical trials

L Hontecillas-Prieto, R Flores-Campos, A Silver… - Frontiers in …, 2020 - frontiersin.org
Chemotherapy is one of the most established and effective treatments for almost all types of
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …

Regulation of chemokines and cytokines by histone deacetylases and an update on histone decetylase inhibitors in human diseases

HR Gatla, N Muniraj, P Thevkar, S Yavvari… - International journal of …, 2019 - mdpi.com
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …

Light‐controlled histone deacetylase (HDAC) inhibitors: towards photopharmacological chemotherapy

W Szymanski, ME Ourailidou… - … A European Journal, 2015 - Wiley Online Library
Cancer treatment suffers from limitations that have a major impact on the patient's quality of
life and survival. In the case of chemotherapy, the systemic distribution of cytotoxic drugs …

Dissecting histone deacetylase 3 in multiple disease conditions: selective inhibition as a promising therapeutic strategy

N Adhikari, T Jha, B Ghosh - Journal of Medicinal Chemistry, 2021 - ACS Publications
The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

[HTML][HTML] HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by …

NGJ Leus, PE van der Wouden… - Biochemical …, 2016 - Elsevier
The increasing number of patients suffering from chronic obstructive pulmonary disease
(COPD) represents a major and increasing health problem. Therefore, novel therapeutic …

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

NGJ Leus, MRH Zwinderman, FJ Dekker - Current opinion in chemical …, 2016 - Elsevier
Highlights•HDAC 3 plays a key role in NF-κB-mediated signaling.•HDAC inhibitors
demonstrate promising anti-inflammatory effects.•Selective HDAC 3 inhibitors have potential …

Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma

R Islam, D Dash, R Singh - Cytokine, 2022 - Elsevier
Asthma being an inflammatory disease of the airways lead to structural alterations in lungs
which often results in the severity of the disease. Curcumin, diferuloylmethane, is well known …

The role of HDAC3 in inflammation: mechanisms and therapeutic implications

N Watson, S Kuppuswamy, WL Ledford… - Frontiers in …, 2024 - frontiersin.org
Histone deacetylases (HDACs) are critical regulators of inflammatory gene expression, and
the efficacy of pan-HDAC inhibitors has been implicated in various disease conditions …

The potential use of l-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence

N Mazarakis, K Snibson, PV Licciardi, TC Karagiannis - Clinical nutrition, 2020 - Elsevier
Summary According to the World Health Organisation, 70% of all deaths globally can be
attributed to chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel …

Formation, immunomodulatory activities, and enhancement of glucosinolates and sulforaphane in broccoli sprouts: a review for maximizing the health benefits to …

L Li, P Ma, S Nirasawa, H Liu - Critical Reviews in Food Science …, 2024 - Taylor & Francis
Broccoli sprouts have been considered as functional foods which have received increasing
attention because they have been highly prized for glucosinolates, phenolics, and vitamins …