Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

Abstract Huntington's disease (HD), caused by expanded CAG repeats encoding a
polyglutamine tract in the huntingtin (HTT) protein, presents with a predominant …

Lentiviral vectors (LVs), derived from human immunodeficiency virus, are powerful tools for
modifying the genes of eukaryotic cells such as hematopoietic stem cells and neural cells …

Cell therapies represent a promising approach to slow down the progression of currently
untreatable neurodegenerative diseases (eg, Alzheimer's and Parkinson's disease or …

Endothelial cells are constantly exposed to environmental stress factors that, above a certain
threshold, trigger cellular senescence and apoptosis. The altered vascular function affects …

Neuronal survival depends on multiple factors that comprise a well‐fueled energy
metabolism, trophic input, clearance of toxic substances, appropriate redox environment …

Huntington disease (HD) is an inherited disorder hallmarked by progressive deterioration of
specific neurons, followed by movement and cognitive anomalies. Cell therapy approaches …