Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands

J Korbecki, S Grochans, I Gutowska, K Barczak… - International journal of …, 2020 - mdpi.com
CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+ …

Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy

B Wang, Q Zhao, Y Zhang, Z Liu, Z Zheng, S Liu… - Journal of Experimental …, 2021 - Springer
With the success of immune checkpoint inhibitors (ICIs), significant progress has been made
in the field of cancer immunotherapy. Despite the long-lasting outcomes in responders, the …

Genetically engineering cell membrane‐coated BTO nanoparticles for MMP2‐activated piezocatalysis‐immunotherapy

Q Tang, S Sun, P Wang, L Sun, Y Wang… - Advanced …, 2023 - Wiley Online Library
Tumor immunotherapy based on immune checkpoint blockade (ICB) still suffers from low
host response rate and non‐specific distribution of immune checkpoint inhibitors, greatly …

HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence

J Fu, X Su, Z Li, L Deng, X Liu, X Feng, J Peng - Oncogene, 2021 - nature.com
This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor
(HGF)/mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers. First …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Tumor-associated macrophages in pancreatic ductal adenocarcinoma: origin, polarization, function, and reprogramming

S Yang, Q Liu, Q Liao - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC is only
cured by surgical resection in its early stage, but there remains a relatively high possibility of …

[HTML][HTML] Ru (II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma

JY Zhou, WJ Wang, CY Zhang, YY Ling, XJ Hong, Q Su… - Biomaterials, 2022 - Elsevier
The alternations in the hypoxic and immune microenvironment are closely related to the
therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new …

Self-propelled Janus nanocatalytic robots guided by magnetic resonance imaging for enhanced tumor penetration and therapy

Z Sun, T Wang, J Wang, J Xu, T Shen… - Journal of the …, 2023 - ACS Publications
Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion
and controllable navigation have made tremendous progress in disease therapy and …

Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges

MZ Noman, M Hasmim, A Lequeux, M Xiao, C Duhem… - Cells, 2019 - mdpi.com
Initially believed to be a disease of deregulated cellular and genetic expression, cancer is
now also considered a disease of the tumor microenvironment. Over the past two decades …