The Hippo pathway has emerged as a conserved signaling pathway that is essential for the
proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms …

Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in
animal morphogenesis. Various cadherin-related molecules have also been identified …

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic
basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent …

Background FAT4 functions as a tumor suppressor, and previous findings have
demonstrated that FAT4 can inhibit the epithelial-to-mesenchymal transition (EMT) and the …

Malformations of the human cortex represent a major cause of disability. Mouse models with
mutations in known causal genes only partially recapitulate the phenotypes and are …

Abstract FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is
involved in tumor suppression and planar cell polarity (PCP). FAT1 and FAT4 undergo the …

Adhesion between cells is essential to the evolution of multicellularity. Indeed,
morphogenesis in animals requires firm but flexible intercellular adhesions that are …

The regulated proliferation and differentiation of neural stem cells before the generation and
migration of neurons in the cerebral cortex are central aspects of mammalian development …

Polarized epithelial cells exhibit a characteristic array of microtubules that are oriented along
the apicobasal axis of the cells. The minus-ends of these microtubules face apically, and the …

The Drosophila Dachsous and Fat proteins function as ligand and receptor, respectively, for
an intercellular signaling pathway that regulates Hippo signaling and planar cell polarity …