Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

Background: Virtual Screening methodologies have emerged as efficient alternatives for the
discovery of new drug candidates. At the same time, ensemble methods are nowadays …

We report one-pot synthesis of a series of new 3-aryl-8-methylquinazolin-4 (3H)-ones (QNZ)
and their antimicrobial activity against Acanthamoeba castellanii belonging to T4 genotype …

The QuBiLs-MAS approach is used for the in silico modelling of the antifungal activity of
organic molecules. To this effect, non-stochastic (NS) and simple-stochastic (SS) atom …

Quinoxalinone derivatives, identified as VAM2 compounds (7-nitroquinoxalin-2-ones), were
evaluated against Toxoplasma gondii tachyzoites of the RH strain. The VAM2 compounds …

Acanthamoeba castellanii is a free-living amoeba which can cause a blinding keratitis and
fatal granulomatous amoebic encephalitis. The treatment of Acanthamoeba infections is …

A facile synthetic approach towards two distinct quinoxaline-based heterocyclic scaffolds
has been developed from the cycloaddition of acyl (quinoxalinyl) ketenes with …

A facile synthetic approach towards two distinct pyrrole-based heterocyclic scaffolds has
been developed by the interaction of 1H-pyrrole-2, 3-diones fused at the [e]-side to a 1, 4 …

Malaria, the most virulent parasitic disease, has become a devastating health problem in
tropical and subtropical regions, especially in Africa, due to favorable temperature and …

Two series of ten novel 7-nitroquinoxalin-2-ones and ten 6-nitroquinoxaline-2, 3-diones with
diverse substituents at positions 1 and 4 were synthesized and evaluated against the …