Multiple-system atrophy is a neurodegenerative disease characterized by progressive
autonomic failure, parkinsonism, and cerebellar and pyramidal tract symptoms. Glial …

Dysfunction of the autonomic nervous system afflicts most patients with Parkinson disease
and other synucleinopathies such as dementia with Lewy bodies, multiple system atrophy …

Objective To define the clinical features and biomarkers that predict which patients with pure
autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders,
particularly in the early stages of the disease. An autonomic-only presentation can be …

Objective To undertake a systematic review and meta-analysis of studies that investigated
prognostic factors and survival in patients with progressive supranuclear palsy (PSP) and …

Abstract See Colosimo and Berardelli (doi: 10.1093/brain/awv303) for a scientific
commentary on this article. Multiple system atrophy is characterized by autonomic failure …

Objective Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia
frequently affecting patients with synucleinopathies, but its exact prevalence in multiple …

Background Orthostatic hypotension (OH) is a sustained fall in blood pressure on standing
that can cause symptoms of organ hypoperfusion. OH is associated with increased morbidity …

Objectives: Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic
failure (PAF) involve cytoplasmic deposition of α-synuclein and are considered to be …