Pre-and Post-Synaptic protein in the major depressive Disorder: From neurobiology to therapeutic targets

RH Silva, LC Pedro, LM Manosso, CL Gonçalves… - Neuroscience, 2024 - Elsevier
Major depressive disorder (MDD) has demonstrated its negative impact on various aspects
of the lives of those affected. Although several therapies have been developed over the …

Increased depression-like behaviors with altered brain dopamine metabolisms in male mice housed in large cages are alleviated by bupropion

K Kurogi, F Taniguchi, R Matsuo, M Shinozuka… - European journal of …, 2023 - Elsevier
Psycho-environmental stress-based animal models of anxiety and depression are useful for
investigating pathological mechanisms and drug development. Although several rodent …

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a …

Ε Dandi, P Theotokis, MC Petri… - Developmental …, 2023 - Wiley Online Library
This study aims at investigating whether environmental enrichment (EE) initiated in
adolescence can alter chronic unpredictable stress (CUS)‐associated changes in astroglial …

Environmental enrichment normalizes metabolic function in the murine model of Prader-Willi syndrome Magel2-null mice

NJ Queen, X Zou, W Huang, T Mohammed… - Endocrinology, 2025 - academic.oup.com
Prader-Willi syndrome (PWS) is a rare genetic disease that causes developmental delays,
intellectual impairment, constant hunger, obesity, endocrine dysfunction, and various …

[HTML][HTML] The influence of long-term housing in enriched environment on behavior of normal rats and subjected to neonatal pro-inflammatory challenge

IV Pavlova, ND Broshevitskaya, MI Zaichenko… - Brain, Behavior, & …, 2023 - Elsevier
It is well known that neonatal pro-inflammatory challenge (NPC) acquire a predisposition to
the development of a number of neuropsychiatric diseases: depression, anxiety disorders …

Environmental enrichment induces depressive-and anxiety-like behaviors in male Balb/C mice

MC de Brito, BY Costa, TA de Souza Lima… - Behavioural Brain …, 2025 - Elsevier
Depression and anxiety disorders are prevalent neuropsychiatric conditions worldwide that
impose substantial economic and social burdens worldwide. Environmental enrichment (EE) …

[HTML][HTML] Environmental enrichment accelerates the acquisition of schedule-induced drinking in rats

E Fuentes-Verdugo, GE López-Tolsa, R Pascual… - Behavioural …, 2023 - Elsevier
Environmental enrichment (EE) provides an improvement in the housing conditions of
experimental animals, such as laboratory rats, with greater physical and social stimulation …

丰富环境训练结合头穴丛刺对孤独症谱系障碍模型大鼠行为的影响

穆姿辰, 唐强, 史云秋, 王艳, 朱淑伟, 庄亚楠… - 中国康复理论与 …, 2024 - cjrtponline.com
目的观察丰富环境训练结合头穴丛刺对孤独症大鼠行为的影响. 方法选择健康雌性Wistar 大鼠,
于妊娠第12.5 天时给予腹腔注射丙戊酸钠, 随机选取子代雄鼠24 只, 随机分为模型组(n= 6) …