Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Senescence mechanisms and targets in the heart

MS Chen, RT Lee, JC Garbern - Cardiovascular research, 2022 - academic.oup.com
Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

[HTML][HTML] Role of miRNA and lncRNAs in organ fibrosis and aging

S Ghafouri-Fard, A Abak, SF Talebi, H Shoorei… - Biomedicine & …, 2021 - Elsevier
Fibrosis is the endpoint of pathological remodeling. This process contributes to the
pathogenesis of several chronic disorders and aging-associated organ damage. Different …

Novel insights into the molecular mechanisms of atherosclerosis

A Wojtasińska, W Frąk, W Lisińska, N Sapeda… - International journal of …, 2023 - mdpi.com
Atherosclerosis is one of the most fatal diseases in the world. The associated thickening of
the arterial wall and its background and consequences make it a very composite disease …

The aging heart: a molecular and clinical challenge

D Lazzeroni, A Villatore, G Souryal, G Pili… - International journal of …, 2022 - mdpi.com
Aging is associated with an increasing burden of morbidity, especially for cardiovascular
diseases (CVDs). General cardiovascular risk factors, ischemic heart diseases, heart failure …

[HTML][HTML] Kaempferol: Paving the path for advanced treatments in aging-related diseases

MS Hussain, ASA Altamimi, M Afzal, WH Almalki… - Experimental …, 2024 - Elsevier
Aging-related diseases (ARDs) are a major global health concern, and the development of
effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has …

[HTML][HTML] SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation resolution of diabetic periodontitis

B Li, Z Xin, S Gao, Y Li, S Guo, Y Fu, R Xu, D Wang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Diabetes exacerbates the prevalence and severity of periodontitis, leading to
severe periodontal destruction and ultimately tooth loss. Delayed resolution of inflammation …

Immunosenescence in atherosclerosis: A role for chronic viral infections

A Ghamar Talepoor, M Doroudchi - Frontiers in Immunology, 2022 - frontiersin.org
Immune system is a versatile and dynamic body organ which offers survival and endurance
of human beings in their hostile living environment. However, similar to other cells, immune …

Theories and molecular basis of vascular aging: a review of the literature from vascagenet group on pathophysiological mechanisms of vascular aging

E Gkaliagkousi, A Lazaridis, S Dogan… - International journal of …, 2022 - mdpi.com
Vascular aging, characterized by structural and functional alterations of the vascular wall, is
a hallmark of aging and is tightly related to the development of cardiovascular mortality and …

The Pathogenic Role of Long Non-coding RNA H19 in Atherosclerosis via the miR-146a-5p/ANGPTL4 Pathway

SF Huang, G Zhao, XF Peng, WC Ye - Frontiers in cardiovascular …, 2021 - frontiersin.org
The abnormally expressed long non-coding RNA (lncRNA) H19 has a crucial function in the
development and progression of cardiovascular disease; however, its role in atherosclerosis …