The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Neuronal voltage-gated calcium channels: structure, function, and dysfunction
BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
Quality control in the endoplasmic reticulum
L Ellgaard, A Helenius - Nature reviews Molecular cell biology, 2003 - nature.com
The endoplasmic reticulum (ER) has a quality-control system for'proof-reading'newly
synthesized proteins, so that only native conformers reach their final destinations. Non …
synthesized proteins, so that only native conformers reach their final destinations. Non …
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond
AC Dolphin - Nature Reviews Neuroscience, 2012 - nature.com
The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …
auxiliary subunits that enhance channel trafficking, increase the expression of functional …
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac …
Background—Cardiac ion channelopathies are responsible for an ever-increasing number
and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that …
and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that …
The β Subunit of Voltage-Gated Ca2+ Channels
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …
contraction, neuronal communication, hormone release, cell division, and gene …
A role for noncoding variation in schizophrenia
A large portion of common variant loci associated with genetic risk for schizophrenia reside
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
Localization and targeting of voltage-dependent ion channels in mammalian central neurons
H Vacher, DP Mohapatra… - Physiological …, 2008 - journals.physiology.org
The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …
governed by the action of voltage-dependent ion channels. The localization of specific …
Auxiliary subunits: essential components of the voltage-gated calcium channel complex
J Arikkath, KP Campbell - Current opinion in neurobiology, 2003 - Elsevier
Voltage-gated calcium channels are important mediators of several physiological processes,
including neuronal excitability and muscle contraction. At the molecular level, the channels …
including neuronal excitability and muscle contraction. At the molecular level, the channels …