Modern drug discovery approaches often use high-content imaging to systematically study
the effect on cells of large libraries of chemical compounds. By automatically screening …

In image-based profiling, software extracts thousands of morphological features of cells from
multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used …

In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Mitochondria are inextricably linked to the development of diseases and cell metabolism
disorders. Super-resolution imaging (SRI) is crucial in enhancing our understanding of …

Morphological and gene expression profiling can cost-effectively capture thousands of
features in thousands of samples across perturbations by disease, mutation, or drug …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

The wide variety of crops in the image of agricultural products and the confusion with the
surrounding environment information makes it difficult for traditional methods to extract crops …

Deep learning has transformed the way large and complex image datasets can be
processed, reshaping what is possible in bioimage analysis. As the complexity and size of …

The identification of genetic and chemical perturbations with similar impacts on cell
morphology can elucidate compounds' mechanisms of action or novel regulators of genetic …

Most variants in most genes across most organisms have an unknown impact on the
function of the corresponding gene. This gap in knowledge is especially acute in cancer …