Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals–a comprehensive review

L Padrela, MA Rodrigues, A Duarte, AMA Dias… - Advanced drug delivery …, 2018 - Elsevier
Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Supercritical and near-critical CO2 in green chemical synthesis and processing

EJ Beckman - The Journal of Supercritical Fluids, 2004 - Elsevier
Carbon dioxide is often promoted as a sustainable solvent, as CO2 is non-flammable,
exhibits a relatively low toxicity and is naturally abundant. However, injudicious use of …

Chitosan-based delivery systems for protein therapeutics and antigens

M Amidi, E Mastrobattista, W Jiskoot… - Advanced drug delivery …, 2010 - Elsevier
Therapeutic peptides/proteins and protein-based antigens are chemically and structurally
labile compounds, which are almost exclusively administered by parenteral injections …

Organic nanoparticles in the aqueous phase—theory, experiment, and use

D Horn, J Rieger - Angewandte Chemie International Edition, 2001 - Wiley Online Library
Many active organic compounds and organic effect materials are poorly soluble in water, or
even insoluble. Aqueous forms of application thus require special formulation techniques to …

[图书][B] Microencapsulation: methods and industrial applications

S Benita - 2005 - taylorfrancis.com
Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from
medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides …

Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent (SAS) process

SM Abuzar, SM Hyun, JH Kim, HJ Park, MS Kim… - International journal of …, 2018 - Elsevier
Poor water solubility and poor bioavailability are problems with many pharmaceuticals.
Increasing surface area by micronization is an effective strategy to overcome these …

Formation of polymer particles with supercritical fluids: A review

SD Yeo, E Kiran - The Journal of Supercritical Fluids, 2005 - Elsevier
Recent developments on particle formation from polymers using supercritical fluids have
been reviewed with an emphasis on articles published during 2000–2003. First, a brief …

Gas-expanded liquids

PG Jessop, B Subramaniam - Chemical reviews, 2007 - ACS Publications
Solvent usage has been linked to waste generation and associated environmental and
economic burdens. Table 1 compares the amount of waste generated relative to products …

Solid dispersions: a review.

K Dhirendra, S Lewis, N Udupa… - Pakistan journal of …, 2009 - search.ebscohost.com
Solid dispersions have attracted considerable interest as an efficient means of improving the
dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article …