Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Background Mitochondrial uncouplers shuttle protons across the inner mitochondrial
membrane via a pathway that is independent of adenosine triphosphate (ATP) synthase …

Background Mitochondrial uncouplers are well-known for their ability to treat a myriad of
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …

Incorporation of heterocycles into drug molecules can enhance physical properties and
biological activity. A variety of heterocyclic groups is available to medicinal chemists, many …

Small-molecule mitochondrial uncouplers are gaining recognition as potential therapeutics
for metabolic diseases such as obesity, diabetes, and nonalcoholic steatohepatitis (NASH) …

Small molecules capable of uncoupling respiration and ATP synthesis in mitochondria are
protective towards various cell malfunctions. Recently (2-fluorophenyl){6-[(2-fluorophenyl) …

Pyrazines are important class of pharmacophores because of their versatility in
pharmacological activity. Pyrazines are among the most widely known heterocyclic …

Small molecule mitochondrial uncouplers have recently garnered great interest for their
potential in treating nonalcoholic steatohepatitis (NASH). In this study, we report the …

Acute myeloid leukemia (AML) is a malignant proliferative disease of myeloid hematopoietic
origin and cannot be treated appropriately at present. This is due to the fact that leukemia …

Aims Mitochondrial uncouplers decrease caloric efficiency and have potential therapeutic
benefits for the treatment of obesity and related metabolic disorders. Herein we investigate …