Polymer–drug conjugate therapeutics: advances, insights and prospects

I Ekladious, YL Colson, MW Grinstaff - Nature reviews Drug discovery, 2019 - nature.com
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

[HTML][HTML] Copper-mediated living radical polymerization (atom transfer radical polymerization and copper (0) mediated polymerization): from fundamentals to …

C Boyer, NA Corrigan, K Jung, D Nguyen… - Chemical …, 2016 - ACS Publications
The discovery of the first “living” radical polymerization by Otsu and co-workers (1) in 1982
heralded the start of a very exciting time for polymer chemists. Since then, a plethora of living …

Therapeutic protein–polymer conjugates: advancing beyond PEGylation

EM Pelegri-O'Day, EW Lin… - Journal of the American …, 2014 - ACS Publications
Protein–polymer conjugates are widely used as therapeutics. All Food and Drug
Administration (FDA)-approved protein conjugates are covalently linked to poly (ethylene …

Smart hybrid materials by conjugation of responsive polymers to biomacromolecules

I Cobo, M Li, BS Sumerlin, S Perrier - Nature materials, 2015 - nature.com
Smart hybrid materials by conjugation of responsive polymers to biomacromolecules | Nature
Materials Skip to main content Thank you for visiting nature.com. You are using a browser …

Polymeric nanostructured materials for biomedical applications

Z Tang, C He, H Tian, J Ding, BS Hsiao, B Chu… - Progress in Polymer …, 2016 - Elsevier
Polymeric nanostructured materials (PNMs), which are polymeric materials in nanoscale or
polymer composites containing nanomaterials, have become increasingly useful for …

[HTML][HTML] Polymer bioconjugates: Modern design concepts toward precision hybrid materials

C Chen, DYW Ng, T Weil - Progress in Polymer Science, 2020 - Elsevier
The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …

The journey of a drug-carrier in the body: an anatomo-physiological perspective

N Bertrand, JC Leroux - Journal of controlled release, 2012 - Elsevier
Recent advances in chemistry and material sciences have witnessed the emergence of an
increasing number of novel and complex nanosized carriers for the delivery of drugs and …

FDA-approved poly (ethylene glycol)–protein conjugate drugs

SNS Alconcel, AS Baas, HD Maynard - Polymer Chemistry, 2011 - pubs.rsc.org
PEGylation or covalent attachment of poly (ethylene glycol) improves the pharmacokinetic
properties of protein drugs. In vivo circulation lifetimes are increased and dosages are …

Nanomaterials for drug delivery

JA Hubbell, A Chilkoti - Science, 2012 - science.org
All drugs face several transport barriers on their tortuous journey from their site of
introduction to their molecular site of action. Critical barriers include rapid filtration in the …

ATRP in the design of functional materials for biomedical applications

DJ Siegwart, JK Oh, K Matyjaszewski - Progress in polymer science, 2012 - Elsevier
Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and
preparation of multifunctional, nanostructured materials for a variety of applications in …