Leveraging artificial intelligence in the fight against infectious diseases
Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …
infectious disease remains an ominous threat to public health. Addressing the challenges …
Elucidating the mechanisms of action of antimicrobial agents
MA Hudson, SW Lockless - MBio, 2022 - Am Soc Microbiol
Despite the ever-growing antibiotic resistance crisis, the rate at which new antimicrobials are
being discovered and approved for human use has rapidly declined over the past 75 years …
being discovered and approved for human use has rapidly declined over the past 75 years …
[PDF][PDF] Genus-wide transcriptional landscapes reveal correlated gene networks underlying microevolutionary divergence in diatoms
Marine microbes like diatoms make up the base of marine food webs and drive global
nutrient cycles. Despite their key roles in ecology, biogeochemistry, and biotechnology, we …
nutrient cycles. Despite their key roles in ecology, biogeochemistry, and biotechnology, we …
Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics
KP Romano, J Bagnall, T Warrier, J Sullivan… - Proceedings of the …, 2024 - pnas.org
The rising prevalence of antibiotic resistance threatens human health. While more
sophisticated strategies for antibiotic discovery are being developed, target elucidation of …
sophisticated strategies for antibiotic discovery are being developed, target elucidation of …
VEBA: a modular end-to-end suite for in silico recovery, clustering, and analysis of prokaryotic, microeukaryotic, and viral genomes from metagenomes
JL Espinoza, CL Dupont - BMC bioinformatics, 2022 - Springer
Background With the advent of metagenomics, the importance of microorganisms and how
their interactions are relevant to ecosystem resilience, sustainability, and human health has …
their interactions are relevant to ecosystem resilience, sustainability, and human health has …
[HTML][HTML] Recent Applications of Explainable AI (XAI): A Systematic Literature Review
M Saarela, V Podgorelec - Applied Sciences, 2024 - mdpi.com
This systematic literature review employs the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses (PRISMA) methodology to investigate recent applications of …
Reviews and Meta-Analyses (PRISMA) methodology to investigate recent applications of …
Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children
Background The specific roles that gut microbiota, known pathogens, and host energy-
regulating hormones play in the pathogenesis of non-edematous severe acute malnutrition …
regulating hormones play in the pathogenesis of non-edematous severe acute malnutrition …
Validating a promoter library for application in plasmid-based diatom genetic engineering
While diatoms are promising synthetic biology platforms, there currently exists a limited
number of validated genetic regulatory parts available for genetic engineering. The standard …
number of validated genetic regulatory parts available for genetic engineering. The standard …
A silent operon of Photorhabdus luminescens encodes a prodrug mimic of GTP
With the overmining of actinomycetes for compounds acting against Gram-negative
pathogens, recent efforts to discover novel antibiotics have been focused on other groups of …
pathogens, recent efforts to discover novel antibiotics have been focused on other groups of …
Differential network analysis of oral microbiome metatranscriptomes identifies community scale metabolic restructuring in dental caries
Dental caries is a microbial disease and the most common chronic health condition,
affecting nearly 3.5 billion people worldwide. In this study, we used a multiomics approach to …
affecting nearly 3.5 billion people worldwide. In this study, we used a multiomics approach to …