Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa

NA Feasey, G Dougan, RA Kingsley, RS Heyderman… - The Lancet, 2012 - thelancet.com
Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of
bloodstream infection in African adults and children, with an associated case fatality of 20 …

Mucosal immunity to pathogenic intestinal bacteria

A Perez-Lopez, J Behnsen, SP Nuccio… - Nature Reviews …, 2016 - nature.com
The intestinal mucosa is a particularly dynamic environment in which the host constantly
interacts with trillions of commensal microorganisms, known as the microbiota, and …

Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive Salmonella infections

JA Crump, M Sjölund-Karlsson… - Clinical microbiology …, 2015 - Am Soc Microbiol
Salmonella enterica infections are common causes of bloodstream infection in low-resource
areas, where they may be difficult to distinguish from other febrile illnesses and may be …

Antimicrobial resistance and management of invasive Salmonella disease

S Kariuki, MA Gordon, N Feasey, CM Parry - Vaccine, 2015 - Elsevier
Invasive Salmonella infections (typhoidal and non-typhoidal) cause a huge burden of illness
estimated at nearly 3.4 million cases and over 600,000 deaths annually especially in …

Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

RA Kingsley, CL Msefula, NR Thomson… - Genome …, 2009 - genome.cshlp.org
Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has
been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan …

Vaccines against invasive Salmonella disease: Current status and future directions

CA MacLennan, LB Martin, F Micoli - Human vaccines & …, 2014 - Taylor & Francis
Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet
under-appreciated global burden of invasive disease. In South and South-East Asia, this …

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

JR Hitchcock, CN Cook, S Bobat… - The Journal of …, 2015 - Am Soc Clin Investig
Thrombosis is a common, life-threatening consequence of systemic infection; however, the
underlying mechanisms that drive the formation of infection-associated thrombi are poorly …

Now you see me, now you don't: the interaction of Salmonella with innate immune receptors

AM Keestra-Gounder, RM Tsolis… - Nature Reviews …, 2015 - nature.com
Salmonella enterica serovars are associated with an estimated 1 million deaths annually
and are also useful model organisms for investigating the mechanisms of host–bacterium …

Immunity to salmonellosis

G Dougan, V John, S Palmer… - Immunological …, 2011 - Wiley Online Library
Salmonella enterica is a genetically broad species harboring isolates that display
considerable antigenic heterogeneity and significant differences in virulence potential …

Invasive Non-Typhi Salmonella Disease in Africa

SC Morpeth, HO Ramadhani… - Clinical infectious …, 2009 - academic.oup.com
Abstract Invasive non-Typhi Salmonella is endemic to sub-Saharan Africa, where it is a
leading cause of bloodstream infection. Some host risk factors have been established, but …