Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management

P Jain, M Wang - American journal of hematology, 2019 - Wiley Online Library
Unprecedented advances in our understanding of the pathobiology, prognostication, and
therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years …

Molecular pathogenesis of mantle cell lymphoma

P Jares, D Colomer, E Campo - The Journal of clinical …, 2012 - Am Soc Clin Investig
Mantle cell lymphoma is a B cell malignancy in which constitutive dysregulation of cyclin D1
and the cell cycle, disruption of DNA damage response pathways, and activation of cell …

Mantle cell lymphoma in 2022—A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel treatments

P Jain, ML Wang - American journal of hematology, 2022 - Wiley Online Library
The field of mantle cell lymphoma (MCL) has witnessed remarkable progress due to
relentless advances in molecular pathogenesis, prognostication, and newer treatments …

Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma

V Fernàndez, O Salamero, B Espinet, F Solé, C Royo… - Cancer research, 2010 - AACR
Mantle cell lymphoma (MCL) is typically a very aggressive disease with poor outcomes, but
some cases display an indolent behavior that might not necessitate treatment at diagnosis …

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era

P Pérez-Galán, M Dreyling… - Blood, The Journal of the …, 2011 - ashpublications.org
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma of which at least a subset
arises from antigen-experienced B cells. However, what role antigen stimulation plays in its …

[HTML][HTML] SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype

A Mozos, C Royo, E Hartmann, D De Jong, C Baró… - …, 2009 - ncbi.nlm.nih.gov
Background Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other
small B-cell lymphomas. The clinical and pathological characteristics of patients with this …

Mantle cell lymphoma: evolving management strategies

E Campo, S Rule - Blood, The Journal of the American Society …, 2015 - ashpublications.org
Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin's lymphoma that
generally affects older individuals and continues to have one of the worst outcomes of all the …

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

NS Saba, D Liu, SEM Herman… - Blood, The Journal …, 2016 - ashpublications.org
To interrogate signaling pathways activated in mantle cell lymphoma (MCL) in vivo, we
contrasted gene expression profiles of 55 tumor samples isolated from blood and lymph …

CCND2 rearrangements are the most frequent genetic events in cyclin D1 mantle cell lymphoma

I Salaverria, C Royo, A Carvajal-Cuenca… - Blood, The Journal …, 2013 - ashpublications.org
Cyclin D1− mantle cell lymphomas (MCLs) are not well characterized, in part because of the
difficulties in their recognition. SOX11 has been identified recently as a reliable biomarker of …

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

MC Vegliante, J Palomero… - Blood, The Journal …, 2013 - ashpublications.org
Mantle cell lymphoma (MCL) is one of the most aggressive lymphoid neoplasms whose
pathogenesis is not fully understood. The neural transcription factor SOX11 is …