A systematic review and meta-analyses of interleukin-1 receptor associated kinase 3 (IRAK3) action on inflammation in in vivo models for the study of sepsis

TH Nguyen, I Turek, T Meehan-Andrews, A Zacharias… - PloS one, 2022 - journals.plos.org
Background Interleukin-1 receptor associated kinase 3 (IRAK3) is a critical modulator of
inflammation and is associated with endotoxin tolerance and sepsis. Although IRAK3 is …

Understanding the role of endotoxin tolerance in chronic inflammatory conditions and periodontal disease

L Larsson, C Garaicoa‐Pazmino… - Journal of clinical …, 2022 - Wiley Online Library
Objective This review aims to present the current understanding of endotoxin tolerance (ET)
in chronic inflammatory diseases and explores the potential connection with periodontitis …

Contrasting immunomodulatory effects of probiotic and pathogenic bacteria on eastern oyster, Crassostrea virginica, larvae

TH Modak, M Gomez-Chiarri - Vaccines, 2020 - mdpi.com
Several Vibrio spp. cause acute and severe mortality events in hatcheries where larvae of
bivalve mollusks are reared, potentially leading to subsequent shortage of bivalve seed for …

A novel lactic acid bacteria mixture: Macrophage-targeted prophylactic intervention in colorectal cancer management

P Hradicka, J Beal, M Kassayova, A Foey… - Microorganisms, 2020 - mdpi.com
Colorectal cancer (CRC) is one of the most common forms of cancer. Its onset from chronic
inflammation is widely accepted. Moreover, dysbiosis plays an undeniable role, thus the use …

Endotoxin tolerance induced by Porphyromonas gingivalis lipopolysaccharide alters macrophage polarization

JY Gu, Z Fu, JL Chen, YJ Liu, X Cao, Y Sun - Microbial pathogenesis, 2022 - Elsevier
Endotoxin tolerance refers to a state refractory to subsequent lipopolysaccharide (LPS)
stimulations following a primary LPS exposure. To study the relationship between endotoxin …

Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review …

TH Nguyen, I Turek, T Meehan-Andrews, A Zacharias… - Plos one, 2020 - journals.plos.org
Background IRAK3 is a critical modulator of inflammation in innate immunity. IRAK3 is
associated with many inflammatory diseases, including sepsis, and is required in endotoxin …

A novel dietary multi-strain yeast fraction modulates intestinal toll-like-receptor signalling and mucosal responses of rainbow trout (Oncorhynchus mykiss)

M Rawling, E Leclercq, A Foey, M Castex… - PLoS One, 2021 - journals.plos.org
This study was conducted to evaluate the mucosal immune responses of rainbow trout when
supplementing an experimental formulated feed with multi-strain yeast fraction product …

MCP-induced protein 1 participates in macrophage-dependent endotoxin tolerance

M Wadowska, E Dobosz, A Golda, D Bryzek… - The Journal of …, 2022 - journals.aai.org
Endotoxin tolerance is a state of hyporesponsiveness to LPS, triggered by previous
exposure to endotoxin. Such an immunosuppressive state enhances the risks of secondary …

Lacticaseibacillus casei Strain Shirota Modulates Macrophage-Intestinal Epithelial Cell Co-Culture Barrier Integrity, Bacterial Sensing and Inflammatory Cytokines

A Foey, N Habil, A Strachan, J Beal - Microorganisms, 2022 - mdpi.com
Probiotic bacteria modulate macrophage immune inflammatory responses, with functional
cytokine responses determined by macrophage subset polarisation, stimulation and …

[HTML][HTML] Role of RP105 and A20 in negative regulation of toll-like receptor activity in fibrosis: potential targets for therapeutic intervention

S Bale, J Varga, S Bhattacharyya - AIMS Allergy and Immunology, 2021 - aimspress.com
Toll-like receptors (TLRs) are essential defensive mediators implicated in immune diseases.
Tight regulation of TLR function is indispensable to avoid the damaging effects of chronic …