The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts
The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous
cell types, including the inflammatory response, cell proliferation, survival, differentiation …
cell types, including the inflammatory response, cell proliferation, survival, differentiation …
Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer
S Vlahopoulos, M Adamaki, N Khoury… - Pharmacology & …, 2019 - Elsevier
Cytokines are pivotal mediators of the immune response, and their coordinated expression
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …
An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module
Aberrant inflammation, such as that associated with inflammatory bowel disease (IBD), is
fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module …
fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module …
PM2.5 Exposure Induces Inflammatory Response in Macrophages via the TLR4/COX-2/NF-κB Pathway
H Fu, X Liu, W Li, Y Zu, F Zhou, Q Shou, Z Ding - Inflammation, 2020 - Springer
Fine particulate matter with an aerodynamic diameter less than 2.5 μm (PM2. 5) is a serious
air pollutant associated with health problems. Macrophages play an important role in the …
air pollutant associated with health problems. Macrophages play an important role in the …
piEnPred: a bi-layered discriminative model for enhancers and their subtypes via novel cascade multi-level subset feature selection algorithm
Enhancers are short DNA cis-elements that can be bound by proteins (activators) to
increase the possibility that transcription of a particular gene will occur. The Enhancers …
increase the possibility that transcription of a particular gene will occur. The Enhancers …
[HTML][HTML] Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode
SA Vlahopoulos - Cancer biology & medicine, 2017 - ncbi.nlm.nih.gov
The role of the transcription factor NF-κB in shaping the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …
Role of the NF-κB system in context-specific tuning of the inflammatory gene response
Highlights•Inflammatory genes are activated in a stimulus-type-specific and cell-type-specific
manner.•Deregulated inflammatory gene expressions have been linked to human …
manner.•Deregulated inflammatory gene expressions have been linked to human …
Advances in molecular agents targeting toll-like receptor 4 signaling pathways for potential treatment of sepsis
Y Zheng, Y Gao, W Zhu, X Bai, J Qi - European Journal of Medicinal …, 2024 - Elsevier
Sepsis is a systemic inflammatory response syndrome caused by an infection. Toll-like
receptor 4 (TLR4) is activated by endogenous molecules released by injured or necrotic …
receptor 4 (TLR4) is activated by endogenous molecules released by injured or necrotic …
Evaluating phenotypic and transcriptomic responses induced by low-level VOCs in Zebrafish: Benzene as an example
Urban environments are plagued by complex mixtures of anthropogenic volatile organic
compounds (VOCs), such as mixtures of benzene, toluene, ethylene, and xylene (BTEX) …
compounds (VOCs), such as mixtures of benzene, toluene, ethylene, and xylene (BTEX) …
Inflammation and tissue homeostasis: The NF-κB system in physiology and malignant progression
Disruption of tissue function activates cellular stress which triggers a number of mechanisms
that protect the tissue from further damage. These mechanisms involve a number of …
that protect the tissue from further damage. These mechanisms involve a number of …