The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts

S Mitchell, R Tsui, ZC Tan, A Pack, A Hoffmann - Science signaling, 2023 - science.org
The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous
cell types, including the inflammatory response, cell proliferation, survival, differentiation …

Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer

S Vlahopoulos, M Adamaki, N Khoury… - Pharmacology & …, 2019 - Elsevier
Cytokines are pivotal mediators of the immune response, and their coordinated expression
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …

An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module

M Chawla, T Mukherjee, A Deka… - Proceedings of the …, 2021 - National Acad Sciences
Aberrant inflammation, such as that associated with inflammatory bowel disease (IBD), is
fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module …

PM2.5 Exposure Induces Inflammatory Response in Macrophages via the TLR4/COX-2/NF-κB Pathway

H Fu, X Liu, W Li, Y Zu, F Zhou, Q Shou, Z Ding - Inflammation, 2020 - Springer
Fine particulate matter with an aerodynamic diameter less than 2.5 μm (PM2. 5) is a serious
air pollutant associated with health problems. Macrophages play an important role in the …

piEnPred: a bi-layered discriminative model for enhancers and their subtypes via novel cascade multi-level subset feature selection algorithm

ZU Khan, D Pi, S Yao, A Nawaz, F Ali, S Ali - Frontiers of Computer …, 2021 - Springer
Enhancers are short DNA cis-elements that can be bound by proteins (activators) to
increase the possibility that transcription of a particular gene will occur. The Enhancers …

[HTML][HTML] Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

SA Vlahopoulos - Cancer biology & medicine, 2017 - ncbi.nlm.nih.gov
The role of the transcription factor NF-κB in shaping the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …

Role of the NF-κB system in context-specific tuning of the inflammatory gene response

M Chawla, P Roy, S Basak - Current opinion in immunology, 2021 - Elsevier
Highlights•Inflammatory genes are activated in a stimulus-type-specific and cell-type-specific
manner.•Deregulated inflammatory gene expressions have been linked to human …

Advances in molecular agents targeting toll-like receptor 4 signaling pathways for potential treatment of sepsis

Y Zheng, Y Gao, W Zhu, X Bai, J Qi - European Journal of Medicinal …, 2024 - Elsevier
Sepsis is a systemic inflammatory response syndrome caused by an infection. Toll-like
receptor 4 (TLR4) is activated by endogenous molecules released by injured or necrotic …

Evaluating phenotypic and transcriptomic responses induced by low-level VOCs in Zebrafish: Benzene as an example

CC Wu, JR Blount, A Haimbaugh, S Heldman… - Toxics, 2022 - mdpi.com
Urban environments are plagued by complex mixtures of anthropogenic volatile organic
compounds (VOCs), such as mixtures of benzene, toluene, ethylene, and xylene (BTEX) …

Inflammation and tissue homeostasis: The NF-κB system in physiology and malignant progression

GI Lambrou, K Hatziagapiou, S Vlahopoulos - Molecular Biology Reports, 2020 - Springer
Disruption of tissue function activates cellular stress which triggers a number of mechanisms
that protect the tissue from further damage. These mechanisms involve a number of …