[HTML][HTML] Innovative strategies to Combat 5-fluorouracil resistance in colorectal cancer: The role of phytochemicals and extracellular vesicles

M Barathan, AK Zulpa, SL Ng, Y Lokanathan… - International Journal of …, 2024 - mdpi.com
Colorectal cancer (CRC) is a significant public health challenge, with 5-fluorouracil (5-FU)
resistance being a major obstacle to effective treatment. Despite advancements, resistance …

Mesenchymal stem cell-derived exosomes: Characteristics and applications in disease pathology and management

H Padinharayil, J Varghese, C Wilson, A George - Life Sciences, 2024 - Elsevier
Mesenchymal stem cells (MSCs) possess a role in tissue regeneration and homeostasis
because of inherent immunomodulatory capacity and the production of factors that …

Application of mesenchymal stem cells exosomes as nanovesicles delivery system in the treatment of breast cancer

X Liu, JH Kim, X Li, R Liu - International Journal of Pharmaceutics, 2024 - Elsevier
As people's living standards continue to improve and human life span expectancy increases,
the incidence and mortality rates of breast cancer are continuously rising. Early detection of …

Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth …

QH Chen, Y Zhang, X Gu, PL Yang… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND Pulmonary fibrosis is one of the main reasons for the high mortality rate
among acute respiratory distress syndrome (ARDS) patients. Mesenchymal stromal cell …

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

JY Ding, MJ Chen, LF Wu, GF Shu, SJ Fang… - Military Medical …, 2023 - Springer
Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or
contusions. As such injuries are common to all human groups, they may at times represent a …

Renal cancer secretome induces migration of mesenchymal stromal cells

P Popławski, W Zarychta-Wiśniewska… - Stem cell research & …, 2023 - Springer
Background Advanced renal cell carcinoma (RCC) is therapeutically challenging. RCC
progression is facilitated by mesenchymal stem/stromal cells (MSCs) that exert remarkable …

ST2-conditioned medium fosters dorsal horn cell excitability and synaptic transmission in cultured mouse spinal cord

EH Juárez, CR Wood, R Davies, O Kehoe… - Stem Cell Reviews and …, 2023 - Springer
Conditioned medium obtained from bone marrow-derived stem cells has been proposed as
a novel cell-free therapy in spinal cord injury and neuropathic pain, yet the direct effect on …

Exosome-functionalized heterogeneous nanofibrous scaffolds repair bone defects accompanied by muscle injury

S Jin, Z Luo, Y Cai, J Wen, P Lu, X Fu, P Mou… - Chemical Engineering …, 2024 - Elsevier
Patients with clinical bone defects often experience varying degrees of muscle injury. Due to
the high heterogeneity of hard and soft tissue structures, the integrated treatment of muscle …

Extraembryonic mesoderm cells derived from human embryonic stem cells rely on Wnt pathway activation

SL Wang, GH Shi, K Duan, Y Yin, T Li - Cell Proliferation, 2024 - Wiley Online Library
Extraembryonic mesoderm cells (EXMCs) are involved in the development of multiple
embryonic lineages and umbilical cord formation, where they subsequently develop into …

Cell Therapies for Acute Radiation Syndrome

BA Christy, MC Herzig, X Wu… - International journal of …, 2024 - mdpi.com
The risks of severe ionizing radiation exposure are increasing due to the involvement of
nuclear powers in combat operations, the increasing use of nuclear power, and the …