The Extent of Human Apolipoprotein AI Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro
R Dal Magro, S Simonelli, A Cox, B Formicola… - Frontiers in …, 2019 - frontiersin.org
Much evidence suggests a protective role of high-density lipoprotein (HDL) and its major
apolipoprotein apoA-I, in Alzheimer's disease (AD). The biogenesis of nascent HDL derived …
apolipoprotein apoA-I, in Alzheimer's disease (AD). The biogenesis of nascent HDL derived …
Cell penetrating peptide modulation of membrane biomechanics by Molecular dynamics
The efficacy of a pharmaceutical treatment is often countered by the inadequate membrane
permeability, that prevents drugs from reaching their specific intracellular targets. Cell …
permeability, that prevents drugs from reaching their specific intracellular targets. Cell …
Structure-based virtual screening, molecular docking, molecular dynamics simulation and pharmacokinetic modelling of cyclooxygenase-2 (COX-2) inhibitor for the …
Colorectal cancer is the third most frequent cause of cancer worldwide and is more
prevalent in older individuals of all ages. The recent statistics from World Health …
prevalent in older individuals of all ages. The recent statistics from World Health …
Multivalent interacting glycodendrimer to prevent amyloid-peptide fibril formation induced by Cu (II): A multidisciplinary approach
A Janaszewska, B Klajnert-Maculewicz… - Nano Research, 2018 - Springer
Amyloid peptide fibrillogenesis induced by Cu (II) ions is a key event in the pathogenesis of
Alzheimer's disease. Dendrimers have been found to be active in preventing fibril formation …
Alzheimer's disease. Dendrimers have been found to be active in preventing fibril formation …
Conformational dynamics and stability of U-shaped and S-shaped amyloid β assemblies
Alzheimer's disease is the most fatal neurodegenerative disorder characterized by the
aggregation and deposition of Amyloid β (Aβ) oligomers in the brain of patients. Two …
aggregation and deposition of Amyloid β (Aβ) oligomers in the brain of patients. Two …
Free energy landscape of siRNA-polycation complexation: Elucidating the effect of molecular geometry, polymer flexibility, and charge neutralization
The success of medical threatments with DNA and silencing interference RNA is strongly
related to the design of efficient delivery technologies. Cationic polymers represent an …
related to the design of efficient delivery technologies. Cationic polymers represent an …
The role of structural polymorphism in driving the mechanical performance of the alzheimer's beta amyloid fibrils
Alzheimer's Disease (AD) is related with the abnormal aggregation of amyloid β-peptides
Aβ1− 40 and Aβ1− 42, the latter having a polymorphic character which gives rise to U-or S …
Aβ1− 40 and Aβ1− 42, the latter having a polymorphic character which gives rise to U-or S …
Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA
The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the
genome” because of its ability to orchestrate protective biological outputs in response to a …
genome” because of its ability to orchestrate protective biological outputs in response to a …
Unveiling the ESR1 conformational stability and screening potent inhibitors for breast cancer treatment
Background: The current study recognizes the significance of estrogen receptor alpha (ERα)
as a member of the nuclear receptor protein family, which holds a central role in the …
as a member of the nuclear receptor protein family, which holds a central role in the …
Characterization of the AXH domain of Ataxin‐1 using enhanced sampling and functional mode analysis
Ataxin‐1 is the protein responsible for the Spinocerebellar ataxia type 1, an incurable
neurodegenerative disease caused by polyglutamine expansion. The AXH domain plays a …
neurodegenerative disease caused by polyglutamine expansion. The AXH domain plays a …