Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup
Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and is
strongly associated with adverse outcomes, including an increased risk of chronic kidney …
strongly associated with adverse outcomes, including an increased risk of chronic kidney …
Biological phenotyping in sepsis and acute respiratory distress syndrome
P Sinha, NJ Meyer, CS Calfee - Annual review of medicine, 2023 - annualreviews.org
Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …
being recognized as one of the principal barriers to finding efficacious targeted therapies …
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies
G Grasselli, CS Calfee, L Camporota, D Poole… - Intensive care …, 2023 - Springer
The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the
European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to …
European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to …
Latent class analysis reveals COVID-19–related acute respiratory distress syndrome subgroups with differential responses to corticosteroids
P Sinha, D Furfaro, MJ Cummings… - American journal of …, 2021 - atsjournals.org
Rationale: Two distinct subphenotypes have been identified in acute respiratory distress
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis
MV Maddali, M Churpek, T Pham… - The lancet respiratory …, 2022 - thelancet.com
Background Two acute respiratory distress syndrome (ARDS) subphenotypes
(hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and …
(hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and …
Blood DNA methylation and COVID-19 outcomes
J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
P Sinha, VE Kerchberger, A Willmore… - The Lancet …, 2023 - thelancet.com
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
Awake prone positioning and oxygen therapy in patients with COVID-19: the APRONOX study
OR Perez-Nieto, D Escarraman-Martinez… - European …, 2022 - Eur Respiratory Soc
Background The awake prone positioning strategy for patients with acute respiratory distress
syndrome is a safe, simple and cost-effective technique used to improve hypoxaemia. We …
syndrome is a safe, simple and cost-effective technique used to improve hypoxaemia. We …
Promises and challenges of personalized medicine to guide ARDS therapy
KD Wick, DF McAuley, JE Levitt, JR Beitler, D Annane… - Critical Care, 2021 - Springer
Identifying new effective treatments for the acute respiratory distress syndrome (ARDS),
including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving …
including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving …
A research agenda for precision medicine in sepsis and acute respiratory distress syndrome: an official American Thoracic Society research statement
Background: Precision medicine focuses on the identification of therapeutic strategies that
are effective for a group of patients based on similar unifying characteristics. The recent …
are effective for a group of patients based on similar unifying characteristics. The recent …