The four Janus kinase (JAK) proteins and seven signal transducer and activator of
transcription (STAT) transcription factors mediate intracellular signal transduction …

Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

The treat-to-target (T2T) concept has improved outcomes for patients with diabetes,
hypertension and rheumatoid arthritis. This therapeutic strategy involves choosing a well …

Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …

The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …

Interferons are potent antiviral cytokines that modulate immunity in response to infection or
other danger signals. In addition to their antiviral functions, type I interferons (IFNα and IFNβ) …

Systemic lupus erythematosus (SLE) is a chronic, multifactorial autoimmune disease with
complex pathogenesis characterized by the imbalance of pro-inflammatory and anti …

Corticosteroid-sparing disease-modifying anti-rheumatic drugs are an area of active
exploration in large vessel vasculitis (LVV), ie, Takayasu arteritis (TAK) and Giant Cell …

Расшифровка механизмов патогенеза иммуновоспалительных ревматических
заболеваний (ИВРЗ) в сочетании с разработкой широкого спектра генно-инженерных …

Combining the diverse expertise of clinical and scientific researchers from across Europe as
well as patient representatives and pharmaceutical industry partners, the HIPPOCRATES …