Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

CR Balistreri, R Monastero - Brain sciences, 2023 - mdpi.com
The term “neuroinflammation” defines the typical inflammatory response of the brain closely
related to the onset of many neurodegenerative diseases (NDs). Neuroinflammation is well …

[HTML][HTML] Thinking outside the brain: gut microbiome influence on innate immunity within neurodegenerative disease

AR Merchak, MKL Bolen, MG Tansey, KB Menees - Neurotherapeutics, 2024 - Elsevier
The complex network of factors that contribute to neurodegeneration have hampered the
discovery of effective preventative measures. While much work has focused on brain-first …

Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

Y Bai, H Ma, Y Zhang, J Li, X Hou, Y Yang… - Neural Regeneration …, 2025 - journals.lww.com
Traumatic brain injury involves complex pathophysiological mechanisms, among which
oxidative stress significantly contributes to the occurrence of secondary injury. In this study …

Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models

K Ritter, P Somnuke, L Hu, EV Griemert… - BMC neuroscience, 2024 - Springer
TBI is a leading cause of death and disability in young people and older adults worldwide.
There is no gold standard treatment for TBI besides surgical interventions and symptomatic …

Research progress on digestive disorders following traumatic brain injury

Y Lin, C Hou, C Wang, R Chen, Y Zhu, Q Zhou… - Frontiers in …, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a prevalent disease that poses a significant threat to global
public health. Digestive dysfunction, as a common complication, is of particular importance …

Fat mass and obesity–mediated m6A modification modulates neuroinflammatory responses after traumatic brain injury

X Chen, J Lai, Z Wu, J Chen, B Yang… - Neural Regeneration …, 2024 - journals.lww.com
The neuroinflammatory response mediated by microglial activation plays an important role
in the secondary nerve injury of traumatic brain injury. The post-transcriptional modification …

Sodium houttuyfonate modulates the lung Th1/Th2 balance and gut microbiota to protect against pathological changes in lung of ovalbumin-induced asthmatic mice

Y Guo, W Cai, W Xie, Y Xu, X Li, C Yu, Q Wu - Journal of Asthma, 2024 - Taylor & Francis
Objective The gut-lung axis involves microbial and product interactions between the lung
and intestine. Antibiotics for chronic asthma can cause intestinal dysbiosis, disrupting this …

The gut–eye axis: from brain neurodegenerative diseases to age-related macular degeneration

Q Jin, S Wang, Y Yao, Q Jiang, K Li - Neural Regeneration …, 2025 - journals.lww.com
Age-related macular degeneration is a serious neurodegenerative disease of the retina that
significantly impacts vision. Unfortunately, the specific pathogenesis remains unclear, and …

Bidirectional regulation of the brain–gut–microbiota axis following traumatic brain injury

X You, L Niu, J Fu, S Ge, J Shi, Y Zhang… - Neural Regeneration …, 2025 - journals.lww.com
Traumatic brain injury is a prevalent disorder of the central nervous system. In addition to
primary brain parenchymal damage, the enduring biological consequences of traumatic …

[HTML][HTML] Dissecting causal relationships between gut microbiome, immune cells, and brain injury: A Mendelian randomization study

L Xian, X Xu, Y Mai, T Guo, Z Chen, X Deng - Medicine, 2024 - journals.lww.com
Increasing literature has affirmed that changes in the gut microbiome (GM) composition were
linked to distinct brain injury (BI) through the gut–brain axis, but it is uncertain if such links …