Functional role of estrogen metabolism in target cells: review and perspectives.
BT Zhu, AH Conney - Carcinogenesis, 1998 - academic.oup.com
Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary
gland, uterus, brain and other target tissues for estrogen action, and this results in the …
gland, uterus, brain and other target tissues for estrogen action, and this results in the …
The estradiol pharmacophore: ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site
GM Anstead, KE Carlson, JA Katzenellenbogen - Steroids, 1997 - Elsevier
The accumulated knowledge on the binding of estradiol (E2) and its analogs and the results
of affinity-labeling studies have been reviewed and are used herein to derive a binding site …
of affinity-labeling studies have been reviewed and are used herein to derive a binding site …
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development
Cytochrome P450s (CYPs) represent a large class of heme-containing enzymes that
catalyze the metabolism of multitudes of substrates both endogenous and exogenous. Until …
catalyze the metabolism of multitudes of substrates both endogenous and exogenous. Until …
Rapid screening of environmental chemicals for estrogen receptor binding capacity.
R Bolger, TE Wiese, K Ervin, S Nestich… - Environmental health …, 1998 - ehp.niehs.nih.gov
Over the last few years, an increased awareness of endocrine disrupting chemicals (EDCs)
and their potential to affect wildlife and humans has produced a demand for practical …
and their potential to affect wildlife and humans has produced a demand for practical …
Cytochrome P450 1B1 (CYP1B1) Pharmacogenetics: Association of Polymorphisms with Functional Differences in Estrogen Hydroxylation Activity
IH Hanna, S Dawling, N Roodi, FP Guengerich, FF Parl - Cancer research, 2000 - AACR
Activation of 17β-estradiol (E2) through the formation of catechol estrogen metabolites, 2-OH-
E2 and 4-OH-E2, and the C-16αhydroxylation product, 16α-OH-E2, has been postulated to …
E2 and 4-OH-E2, and the C-16αhydroxylation product, 16α-OH-E2, has been postulated to …
Breast Cancer Risk Associated with Genotype Polymorphism of the Estrogen-metabolizing Genes CYP17, CYP1A1, and COMT A Multigenic Study on Cancer …
CS Huang, HD Chern, KJ Chang, CW Cheng, SM Hsu… - Cancer research, 1999 - AACR
Estrogen has been proposed to trigger breast cancer development via an initiating
mechanism involving its metabolite, catechol estrogen (CE). To examine this hypothesis, we …
mechanism involving its metabolite, catechol estrogen (CE). To examine this hypothesis, we …
Endogenous estrogens—breast cancer and chemoprevention
B Starek-Świechowicz, B Budziszewska… - Pharmacological …, 2021 - Springer
Breast cancer is the most common female malignancy and the second leading cause of
cancer related deaths. It is estimated that about 40% of all cancer in women is hormonally …
cancer related deaths. It is estimated that about 40% of all cancer in women is hormonally …
The multifarious link between cytochrome P450s and cancer
AM Alzahrani, P Rajendran - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an
important role in the metabolism of endogenous as well as exogenous substances …
important role in the metabolism of endogenous as well as exogenous substances …
Role of quinoids in estrogen carcinogenesis
JL Bolton, E Pisha, F Zhang… - Chemical research in …, 1998 - pubmed.ncbi.nlm.nih.gov
Role of quinoids in estrogen carcinogenesis Role of quinoids in estrogen carcinogenesis
Chem Res Toxicol. 1998 Oct;11(10):1113-27. doi: 10.1021/tx9801007. Authors JL Bolton 1 …
Chem Res Toxicol. 1998 Oct;11(10):1113-27. doi: 10.1021/tx9801007. Authors JL Bolton 1 …