Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Hematopoietic stem cell factors: their functional role in self-renewal and clinical aspects

Z Mann, M Sengar, YK Verma, R Rajalingam… - Frontiers in Cell and …, 2022 - frontiersin.org
Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy

S Trino, D Lamorte, A Caivano, L De Luca, A Sgambato… - Leukemia, 2021 - nature.com
In the era of precision medicine, liquid biopsy is becoming increasingly important in
oncology. It consists in the isolation and analysis of tumor-derived biomarkers, including …

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

R Lane, T Simon, M Vintu, B Solkin, B Koch… - Communications …, 2019 - nature.com
Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options
and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and …

Comparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease

K Barreiro, OP Dwivedi, G Leparc… - Journal of …, 2020 - Wiley Online Library
Abstract Urinary Extracellular Vesicles (uEV) have emerged as a source for biomarkers of
kidney damage, holding potential to replace the conventional invasive techniques including …

[HTML][HTML] Extracellular vesicles in the hematopoietic microenvironment

JT Butler, S Abdelhamed, P Kurre - Haematologica, 2018 - ncbi.nlm.nih.gov
Self-renewal and differentiation are defining characteristics of hematopoietic stem and
progenitor cells, and their balanced regulation is central to lifelong function of both blood …

The emerging role of exosomes in multiple myeloma

M Moloudizargari, M Abdollahi, MH Asghari, AA Zimta… - Blood Reviews, 2019 - Elsevier
Multiple myeloma (MM), one of the most prevalent hematological malignancies, accounts for
approximately 10% of all blood cancers. In spite of the recent advancements in MM therapy …

Advances in exosome isolation methods and their applications in proteomic analysis of biological samples

R Hou, Y Li, Z Sui, H Yuan, K Yang, Z Liang… - Analytical and …, 2019 - Springer
Exosomes are membrane-bound vesicles secreted by cells, and contain various important
biological molecules, such as lipids, proteins, messenger RNAs, microRNAs, and noncoding …

Challenges and opportunities in clinical applications of blood-based proteomics in cancer

R Bhawal, AL Oberg, S Zhang, M Kohli - Cancers, 2020 - mdpi.com
Simple Summary The traditional approach in identifying cancer related protein biomarkers
has focused on evaluation of a single peptide/protein in tissue or circulation. At best, this …

Proteomics of extracellular vesicles: update on their composition, biological roles and potential use as diagnostic tools in atherosclerotic cardiovascular diseases

A Mallia, E Gianazza, B Zoanni, M Brioschi, SS Barbieri… - Diagnostics, 2020 - mdpi.com
Extracellular vesicles (EVs) are lipid-bound vesicles released from cells under physiological
and pathological conditions. Basing on biogenesis, dimension, content and route of …