Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

B cell lymphomas are cancers that arise from cells that depend on numerous highly
orchestrated interactions with immune and stromal cells in the course of normal …

Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …

ABCG2 is a member of the ATP binding cassette (ABC) transporters, which can pump a wide
variety of endogenous and exogenous compounds out of cells. Widely expressed in stem …

Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity
to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the …

Urate homeostasis in humans is a complex and highly heritable process that involves ie,
metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate …

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …

The Hedgehog pathway is a critical mediator of embryonic patterning and organ
development, including hematopoiesis. It influences stem cell fate, differentiation …

Successful treatment of diffuse large B-cell lymphoma (DLBCL) is frequently hindered by the
development of resistance to conventional chemotherapy resulting in disease relapse and …