On the foundations of cancer modelling: selected topics, speculations, and perspectives

N Bellomo, NK Li, PK Maini - Mathematical Models and Methods in …, 2008 - World Scientific
This paper presents a critical review of selected topics related to the modelling of cancer
onset, evolution and growth, with the aim of illustrating, to a wide applied mathematical …

From the mathematical kinetic, and stochastic game theory to modelling mutations, onset, progression and immune competition of cancer cells

N Bellomo, M Delitala - Physics of Life Reviews, 2008 - Elsevier
This paper deals with a review and critical analysis on the mathematical kinetic theory of
active particles applied to the modelling of the very early stage of cancer phenomena …

Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations

LG de Pillis, W Gu, AE Radunskaya - Journal of theoretical biology, 2006 - Elsevier
We develop and analyze a mathematical model, in the form of a system of ordinary
differential equations (ODEs), governing cancer growth on a cell population level with …

Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls

LG de Pillis, W Gu, KR Fister, TA Head, K Maples… - Mathematical …, 2007 - Elsevier
We investigate a mathematical model of tumor–immune interactions with chemotherapy, and
strategies for optimally administering treatment. In this paper we analyze the dynamics of …

A chemotaxis model motivated by angiogenesis

L Corrias, B Perthame, H Zaag - Comptes Rendus Mathematique, 2003 - Elsevier
We consider a simple model arising in modeling angiogenesis and more specifically the
development of capillary blood vessels due to an exogenous chemo-attractive signal (solid …

Mathematical topics on the modelling complex multicellular systems and tumor immune cells competition

N Bellomo, A Bellouquid, M Delitala - Mathematical Models and …, 2004 - World Scientific
This paper deals with a critical analysis and some developments related to the mathematical
literature on multiscale modelling of multicellular systems involving tumor immune cells …

Multiscale modeling and mathematical problems related to tumor evolution and medical therapy

N Bellomo, E De Angelis… - … Mathematical Methods in …, 2003 - Wiley Online Library
This paper provides a survey of mathematical models and methods dealing with the analysis
and simulation of tumor dynamics in competition with the immune system. The characteristic …

Mathematical methods and tools of kinetic theory towards modelling complex biological systems

A Bellouquid, M Delitala - … models and methods in applied sciences, 2005 - World Scientific
This paper develops a variety of mathematical tools to model the dynamics of large systems
of interacting cells. Interactions are ruled not only by laws of classical mechanics, but also by …

[图书][B] Towards a mathematical theory of complex biological systems

N Bellomo, C Bianca - 2011 - books.google.com
This monograph has the ambitious aim of developing a mathematical theory of complex
biological systems with special attention to the phenomena of ageing, degeneration and …

On the interplay between mathematics and biology: Hallmarks toward a new systems biology

N Bellomo, A Elaiw, AM Althiabi, MA Alghamdi - Physics of life reviews, 2015 - Elsevier
This paper proposes a critical analysis of the existing literature on mathematical tools
developed toward systems biology approaches and, out of this overview, develops a new …