The peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear
receptor superfamily, a group of transcription factors that regulate expression of their target …

Precision cut lung slices (PCLS) have emerged as powerful experimental tools for
respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary …

Rationale: The NF-E2 related factor 2 (Nrf2)–antioxidant response element (ARE) pathway
is essential for protection against oxidative injury and inflammation including hyperoxia …

Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription
factors that belong to the nuclear hormone receptor superfamily. PPARγ regulates several …

Pulmonary fibrosis is a group of disorders characterized by accumulation of scar tissue in
the lung interstitium, resulting in loss of alveolar function, destruction of normal lung …

Lung inflammatory diseases, such as acute lung injury (ALI), asthma, chronic obstructive
pulmonary disease (COPD) and lung fibrosis, represent a major health problem worldwide …

Asthma affects approximately 300 million people worldwide, significantly impacting quality of
life and healthcare costs. While current therapies are effective in controlling many patients' …

Sirtuins are a unique class of NAD+-dependent deacetylases that regulate diverse
biological functions such as aging, metabolism, and stress resistance. Recently, it has been …

Inflammatory diseases of the lung such as asthma and COPD represent a major worldwide
health problem. There are potent antiinflammatory drugs available to treat asthma, such as …

Chronic obstructive pulmonary disease (COPD) is a highly prevalent, chronic inflammatory
lung disease with limited existing therapeutic options. While modulation of peroxisome …