Oxindole has been shown to be a pharmacologically advantageous scaffold having many
biological properties that are relevant to medicinal chemistry. The simplicity and widespread …

Rheumatoid arthritis (RA) is a serious disorder of the joints affecting 1 or 2% of the
population aged between 20 and 50 years worldwide. RA is the foremost cause of disability …

Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the joints, with the main clinical manifestations being chronic, symmetrical, and peripheral …

Aim Hepatic ischemia reperfusion injury (HIRI) is a leading cause of mortality post liver
transplantation, hypovolemic shock and trauma. In this study, we tested, on molecular bases …

A novel strategy to access unsymmetrically linked heterocycles via palladium-catalyzed
acylcycloimidoylation of alkyne-tethered carbamoyl chlorides with isocyanides has been …

Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is compared to “immortal
cancer” in industry. Currently, SYK, BTK, and JAK are the three major targets of protein …

A series of novel (2-oxoindolin-3-ylidene) methyl)-1H-pyrazole and their fused derivatives
bearing oxindole moiety have been designed and successfully synthesized to and …

Rheumatoid arthritis (RA) is a chronic disease that seriously affects human health and
quality of life, and it is one of the main causes of labor loss and disability. Many countries …

Generally, heterocyclic compounds are included in a large class of pharmacologically active
compounds. The indole scaffold in this category is widely distributed in nature and present in …