The canonical mechanism of organophosphate (OP) neurotoxicity is the inhibition of
acetylcholinesterase (AChE). However, multiple lines of evidence suggest that mechanisms …

This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

The toxicology field is concerned with the impact of organophosphorus (OP) compounds on
human health. These compounds have been linked to an increased risk of neurological …

Organophosphates (OPs) refers to a diverse group of phosphorus-containing organic
compounds; they are widely used all over the world and have had an important beneficial …

Many neurodegenerative disorders have lysosomal impediments, and the list of proposed
treatments targeting lysosomes is growing. We investigated the role of lysosomes in …

Due to their inhibition of acetylcholinesterase, organophosphates are among the most toxic
of chemicals. Pralidoxime (aka 2-PAM) is the only acetylcholinesterase reactivator approved …

Alzheimer's disease (AD) poses a critical public health challenge, and there is an urgent
need for novel treatment options. Glutamate, the principal excitatory neurotransmitter in the …

Background Catalpol, an important compound found in Rehmannia glutinosa (a plant with
high nutritional and antidepressant medicinal value), exhibits various biological activities …

The endosomal-lysosomal pathways and related autophagic processes are responsible for
proteostasis, involving complexes between lysosomes and autophagosomes. Lysosomes …

Long pentraxin PTX3, a pattern recognition molecule involved in innate immune responses,
is upregulated by pro-inflammatory stimuli, contributors to secondary damage in traumatic …