Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy

MJ Dobrzanski - Frontiers in oncology, 2013 - frontiersin.org
The importance of CD4 T cells in orchestrating the immune system and their role in inducing
effective T cell-mediated therapies for the treatment of patients with select established …

Targeting interleukin-10 signalling for cancer immunotherapy, a promising and complicated task

G Ni, L Zhang, X Yang, H Li, B Ma… - Human vaccines & …, 2020 - Taylor & Francis
ABSTRACT Interleukin 10 (IL-10) belongs to IL-10 family cytokines that are critical for
maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing …

Immune regulation of cancer

ML Disis - Journal of Clinical Oncology, 2010 - ascopubs.org
Innate and adaptive immune system cells play a major role in regulating the growth of
cancer. Although it is commonly thought that an immune response localized to the tumor will …

Prevention and treatment of papillomavirus-related cancers through immunization

IH Frazer, GR Leggatt… - Annual review of …, 2011 - annualreviews.org
Cervical and other anogenital cancers are initiated by infection with one of a small group of
human papillomaviruses (HPV). Virus-like particle-based vaccines have recently been …

[HTML][HTML] Modulation of antigen presenting cell functions during chronic HPV infection

AA Bashaw, GR Leggatt, J Chandra, ZK Tuong… - Papillomavirus …, 2017 - Elsevier
High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some
individuals they evade host immune responses and persist. Persistent HR-HPV infection of …

Manipulating IL-10 signalling blockade for better immunotherapy

G Ni, T Wang, S Walton, B Zhu, S Chen, X Wu… - Cellular …, 2015 - Elsevier
Interleukin 10 is a cytokine with the ability to reduce or terminate inflammation. Chronic viral
infection, such as infection of chronic hepatitis B, hepatitis C and HIV, has increased levels …

Regulation of immune responses to HPVinfection and during HPV‐directed immunotherapy

P Bhat, SR Mattarollo, C Gosmann… - Immunological …, 2011 - Wiley Online Library
The recent development of vaccines prophylactic against human papillomavirus (HPV)
infection has the potential to reduce the incidence of cervical cancer globally by up to 70 …

Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade

H Lu, WM Wagner, E Gad, Y Yang, H Duan… - The Journal of …, 2010 - journals.aai.org
Multiple TLR agonists have been shown to have antitumor effects in animal models.
However, the therapeutic efficacy of TLR agonist monotherapy in cancer treatment has been …

Recent progress in vaccination against human papillomavirus‐mediated cervical cancer

SJ McKee, AS Bergot… - Reviews in medical …, 2015 - Wiley Online Library
It has been more than 7 years since the commercial introduction of highly successful
vaccines protecting against high‐risk human papillomavirus (HPV) subtypes and the …

Vaccine against scabies: necessity and possibility

X Liu, S Walton, K Mounsey - Parasitology, 2014 - cambridge.org
Scabies is an infectious disease that is endemic in poorly resourced communities, and also
common in industrialized countries. Although the disease, which is caused by infestation of …