Alpha-1-antitrypsin (A1AT) deficiency is an autosomal hereditary disorder associated with a
major reduction in serum A1AT levels. Clinically, A1AT deficiency is associated with …

Over recent decades, therapeutic proteins have had widespread success in treating a
myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical …

Hereditary deficiency of the protein α-1 antitrypsin (AAT) causes a chronic lung disease in
humans that is characterized by excessive mobilization of neutrophils into the lung …

Hydrogen peroxide is a component of cigarette smoke known to be essential for inactivation
of α 1-antitrypsin, the primary inhibitor of neutrophil elastase. To establish the molecular …

We have developed the yeast Kluyveromyces lactis as a host organism for the production of
the milk-clotting enzyme chymosin. In contrast to Saccharomyces cerevisiae, we found that …

1 Recombinant human erythropoietin has N‐linked sugar [Tsuda et al.,(1988) Biochemistry
27, 5646–5654]. Here we have demonstrated the presence of O‐linked sugar (0.85 mol/mol …

Alpha 1-antitrypsin (alpha 1AT) deficiency resulting from homozygous inheritance of the Z-
type alpha 1AT gene is associated with serum alpha 1AT levels of less than 50 mg/dl and …

This reference/text covers fundamentals of peptide and protein drug delivery, including such
considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and …

Chronic inflammatory lung diseases such as cystic fibrosis and emphysema are
characterized by higher‐than‐normal levels of pulmonary proteases. While these enzymes …

The roles of the catalytic active-site residues aspartic acid-52 and glutamic acid-35 of
chicken lysozyme (EC 3.2. 1.17) have been investigated by separate in vitro mutagenesis of …