LFA-1 in T cell priming, differentiation, and effector functions

A Gérard, AP Cope, C Kemper, R Alon, R Köchl - Trends in immunology, 2021 - cell.com
The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and
for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly …

Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion

KH Johansen, DP Golec, K Okkenhaug… - Trends in …, 2023 - cell.com
Following stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple
intracellular signals to initiate T cell proliferation, migration, gene expression, and …

Antigen discrimination by T cells relies on size-constrained microvillar contact

E Jenkins, M Körbel, C O'Brien-Ball, J McColl… - Nature …, 2023 - nature.com
T cells use finger-like protrusions called 'microvilli'to interrogate their targets, but why they do
so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer …

Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus

Y Wang, Y Xie, J Luo, M Guo, X Hu, X Chen, Z Chen… - Nano Today, 2021 - Elsevier
Effective vaccines are vital to fight against the COVID-19 global pandemic. As a critical
component of a subunit vaccine, the adjuvant is responsible for strengthening the antigen …

UTAP: user-friendly transcriptome analysis pipeline

R Kohen, J Barlev, G Hornung, G Stelzer… - BMC …, 2019 - Springer
Background RNA-Seq technology is routinely used to characterize the transcriptome, and to
detect gene expression differences among cell types, genotypes and conditions. Advances …

Intercellular adhesion molecule 1: more than a leukocyte adhesion molecule

CD Haydinger, LM Ashander, ACR Tan, JR Smith - Biology, 2023 - mdpi.com
Simple Summary Intercellular adhesion molecule 1 (ICAM-1) is a protein produced by cells
in blood vessel walls, as well as many other cell types. It localizes to the surface of these …

ICAMs in immunity, intercellular adhesion and communication

C Guerra-Espinosa, M Jiménez-Fernández… - Cells, 2024 - mdpi.com
Interactions among leukocytes and leukocytes with immune-associated auxiliary cells
represent an essential feature of the immune response that requires the involvement of cell …

Multi-compartment 3D-cultured organ-on-a-chip: towards a biomimetic lymph node for drug development

A Shanti, B Samara, A Abdullah, N Hallfors, D Accoto… - Pharmaceutics, 2020 - mdpi.com
The interaction of immune cells with drugs and/or with other cell types should be
mechanistically investigated in order to reduce attrition of new drug development. However …

Intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 differentially contribute to peripheral activation and CNS entry of autoaggressive Th1 and Th17 cells in …

N Haghayegh Jahromi, L Marchetti, F Moalli… - Frontiers in …, 2020 - frontiersin.org
In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
(MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 …

Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact

S Kumari, M Mak, YC Poh, M Tohme, N Watson… - The EMBO …, 2020 - embopress.org
When migratory T cells encounter antigen‐presenting cells (APCs), they arrest and form
radially symmetric, stable intercellular junctions termed immunological synapses which …