Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …

Macrophages are one of the first innate immune cells to reach the site of infection or injury.
Diverse functions from the uptake of pathogen or antigen, its killing, and presentation, the …

Microglia are brain-resident macrophages with trophic and phagocytic functions. Dominant
loss-of-function mutations in a key microglia regulator, colony-stimulating factor 1 receptor …

Abstract Hematopoietic Stem Cell (HSC) gene therapy (GT) may provide lifelong
reconstitution of the hematopoietic system with gene-corrected cells1. However, the effects …

Objective: Previous studies have shown that deficiency of M-CSF (macrophage colony-
stimulating factor; or CSF1 [colony stimulating factor 1]) dramatically reduces atherosclerosis …

Molecular programs initiating cell fate divergence (CFD) are difficult to identify. Current
approaches usually compare cells long after CFD initiation, therefore missing molecular …

How hematopoietic stem cells (HSCs) integrate signals from their environment to make fate
decisions remains incompletely understood. Current knowledge is based on either averages …

The proliferation, differentiation, and survival of cells of the macrophage lineage depends
upon signals from the macrophage colony-stimulating factor (CSF) receptor (CSF1R) …

Liquid handling robots have the potential to automate many procedures in life sciences.
However, they are not in widespread use in academic settings, where funding, space and …

Cells can use signaling pathway activity over time (ie, dynamics) to control cell fates.
However, little is known about the potential existence and function of signaling dynamics in …