Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to
50% of the cell mass of human tumors. TAMs are highly heterogeneous cells that originate …

It has been recently recognized that the tumor microenvironment (TME) is an essential factor
that defines the efficiency of chemotherapy. The local TME, consisting of immune cells with …

Tumor-associated macrophages (TAMs) constitute the main population of immune cells
present in the ovarian tumor microenvironment. These cells are characterized by high …

The accumulation of tumor infiltrating lymphocytes (TILs) in ovarian cancer is prognostic for
increased survival while increases in immunosuppressive regulatory T-cells (Tregs) are …

Ovarian cancer is the most lethal gynecological malignancy worldwide. Most patients are
diagnosed at late stages because of atypical symptoms and the lack of effective early …

Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Since immune cells represent a large fraction of the TME, they play a key role in …

Despite chemotherapy and surgical debulking options, ovarian cancer recurs and
disseminates frequently, with poor prognosis. However, the molecular mechanisms …

Immunotherapy as a treatment for cancer is a growing field of endeavor but reports of
success have been limited for epithelial ovarian cancer. Overcoming the challenges to …

Ovarian cancer is the leading cause of death in women with gynecological malignancy and
improvements in current treatments are needed. As with many other solid cancers, the …