[HTML][HTML] The virtual epileptic patient: individualized whole-brain models of epilepsy spread

VK Jirsa, T Proix, D Perdikis, MM Woodman, H Wang… - Neuroimage, 2017 - Elsevier
Individual variability has clear effects upon the outcome of therapies and treatment
approaches. The customization of healthcare options to the individual patient should …

Pushing the boundaries of neuroimaging with optoacoustics

SV Ovsepian, I Olefir, G Westmeyer, D Razansky… - Neuron, 2017 - cell.com
With the central ability to visualize a variety of endogenous chromophores and biomarkers
or exogenous contrast agents, optoacoustic (photoacoustic) imaging empowers new …

On the nature of seizure dynamics

VK Jirsa, WC Stacey, PP Quilichini, AI Ivanov… - Brain, 2014 - academic.oup.com
Seizures can occur spontaneously and in a recurrent manner, which defines epilepsy; or
they can be induced in a normal brain under a variety of conditions in most neuronal …

Individual brain structure and modelling predict seizure propagation

T Proix, F Bartolomei, M Guye, VK Jirsa - Brain, 2017 - academic.oup.com
Abstract See Lytton (doi: 10.1093/awx018) for a scientific commentary on this article. Neural
network oscillations are a fundamental mechanism for cognition, perception and …

Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy

T Proix, VK Jirsa, F Bartolomei, M Guye… - Nature …, 2018 - nature.com
Recent studies have shown that seizures can spread and terminate across brain areas via a
rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset …

Nonconvulsive seizures after subarachnoid hemorrhage: multimodal detection and outcomes

J Claassen, A Perotte, D Albers, S Kleinberg… - Annals of …, 2013 - Wiley Online Library
Objective Seizures have been implicated as a cause of secondary brain injury, but the
systemic and cerebral physiologic effects of seizures after acute brain injury are poorly …

Acute focal seizures start as local synchronizations of neuronal ensembles

M Wenzel, JP Hamm, DS Peterka… - Journal of …, 2019 - Soc Neuroscience
Understanding seizure formation and spread remains a critical goal of epilepsy research.
We used fast in vivo two-photon calcium imaging in male mouse neocortex to reconstruct …

How does the ketogenic diet work? Four potential mechanisms

NN Danial, AL Hartman… - Journal of child …, 2013 - journals.sagepub.com
The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can
also have antiepileptogenic properties and can eventually have a role in treating other …

Seizure‐induced microvascular injury is associated with impaired neurovascular coupling and blood–brain barrier dysfunction

O Prager, L Kamintsky, LA Hasam‐Henderson… - …, 2019 - Wiley Online Library
Objective Blood–brain barrier (BBB) impairment, redistribution of pericytes, and
disturbances in cerebral blood flow may contribute to the increased seizure propensity and …

Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy

T Proix, F Bartolomei, P Chauvel… - Journal of …, 2014 - Soc Neuroscience
Brain regions generating seizures in patients with refractory partial epilepsy are referred to
as the epileptogenic zone (EZ). During a seizure, paroxysmal activity is not restricted to the …