Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Abstract Purpose of Review African-Americans disproportionately suffer from leading causes
of morbidity and mortality including cardiovascular disease (CVD), cancer, and preterm birth …

Netrin-1 is upregulated in a large fraction of human neoplasms. In multiple animal models,
interference with netrin-1 is associated with inhibition of tumor growth and metastasis …

Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …

Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread
metastatic cancers. Most current approaches rely on the use of vectors to deliver …

Dependence receptors are known to promote survival and positive signaling such as
proliferation, migration, and differentiation when activated, but to actively trigger apoptosis …

Recent studies have shown that peripheral nerves play an important role in the progression
of breast cancer. Breast cancer cells (BCCs) promote local peripheral nerve growth and …

Recent cancer studies have found that the netrin family of proteins plays vital roles in the
development of some cancers. However, the functions of the many variants of these proteins …

Transmembrane receptors are usually seen as on and off switches: when the specific ligand
is bound, the receptor is on and transduces a downstream signal, whereas when the ligand …

Summary c-Kit is a classic proto-oncogene either mutated or upregulated in cancer cells,
and this leads to its constitutive kinase activation and, thus, to uncontrolled proliferation …