The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In
prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor …

Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

The transport of proteins across or into membranes is a vital biological process, achieved in
every cell by the conserved Sec machinery. In bacteria, SecYEG combines with the SecA …

The Sec translocon is a highly conserved membrane assembly for polypeptide transport
across, or into, lipid bilayers. In bacteria, secretion through the core channel complex …

Protein translocation across cell membranes is a ubiquitous process required for protein
secretion and membrane protein insertion. In bacteria, this is mostly mediated by the …

Proteins that misfold in the endoplasmic reticulum (ER) need to be transported back to the
cytosol for degradation by proteasomes, a process known as ER-associated degradation …

The universally conserved Sec system is the primary method cells utilize to transport
proteins across membranes. Until recently, measuring the activity—a prerequisite for …

More than a third of all bacterial polypeptides, comprising the 'exportome', are transported to
extracytoplasmic locations. Most of the exportome is targeted and inserts into …