This mini-review focuses on leishmanicidal drugs that were sourced from small molecules
previously approved for other diseases. The mechanisms of action of these molecules are …

Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

Growing concern for public health has increased the need to change the paradigm towards
a healthcare system that advocates holistic practices while reducing adverse effects. Herbal …

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen
independent lines of Leishmania mexicana and one L. infantum line were selected for …

Liposomal amphotericin B is an important frontline drug for the treatment of visceral
leishmaniasis, a neglected disease of poverty. The mechanism of action of amphotericin B …

Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to
pose global health challenges. Current treatments face issues like resistance, safety …

Leishmania donovani, an obligatory intracellular flagellate pathogen, is the underlying
cause of visceral leishmaniasis (VL), a fatal disease that poses a significant challenge to …

Abstract Background Cutaneous Leishmaniasis (CL) remains a significant public health
concern, particularly in the tropical and subtropical regions. Present treatment options for CL …

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases.
Administration of the drug in its liposomal formulation as a single injection is being promoted …

Limited knowledge on the exact functions of ergostane‐based sterols has hampered the
application of sterol synthesis inhibitors against trypanosomatid parasites. Sterol …